Arsenic concentrations were measured in 992 drinking water samples collected from New Hampshire households using online hydride generation ICP-MS. These randomly selected household water samples contain much less arsenic than those voluntarily submitted for analysis to the New Hampshire Department of Environmental Services (NHDES). Extrapolation of the voluntarily submitted sample set to all Ne...

BACKGROUND Accumulating evidence indicates that in utero exposure to arsenic is associated with congenital defects and long-term disease consequences including cancers. Recent studies suggest that arsenic carcinogenesis results from epigenetic changes, particularly in DNA methylation. This study aimed to investigate DNA methylation changes as a result of arsenic exposure in utero and in vitro. ...

Chronic exposure to arsenic is associated with increased morbidity and mortality from cardiovascular disease (CVD); however, plausible biomarker for early prediction and the underlying mechanism of arsenic-related CVD have not yet been clearly understood. Endothelial dysfunction plays a central role in the development of CVD. We hypothesized that endothelial damage or dysfunction is an importan...

BACKGROUND Exposure to arsenic is a critical risk factor in the complex interplay among genetics, the environment, and human disease. Despite the potential for in utero exposure, the mechanism of arsenic action on vertebrate development and disease is unknown. OBJECTIVES The objective of this study was to identify genes and gene networks perturbed by arsenic during development in order to enh...

BACKGROUND Arsenic is an immunotoxicant. Clinical reports observe the reactivation of varicella zoster virus (VZV) in people who have recovered from arsenic poisoning and in patients with acute promyelocytic leukemia that have been treated with arsenic trioxide. OBJECTIVE We evaluated the association between arsenic and the seroprevalence of VZV IgG antibody in a representative sample of the ...

conclusions given the high levels of arsenic in the rivash water sources, it is essential that a plan be devised to replace the current supply with safe drinking water. moreover, these water resources should be monitored regularly regarding the risk of contamination with arsenic. results the average arsenic levels in stations a, b, c, d, e, f, g, h, i, and j were 1.53 ± 1.03, 1.30 ± 1.07, 10.55...

OBJECTIVE Few biomarkers for dietary intake of various food groups have been established. The aim of the present study was to explore whether selenium (Se), iodine, mercury (Hg) or arsenic may serve as a biomarker for total fish and seafood intake in addition to the traditionally used n-3 fatty acids EPA and DHA. DESIGN Intake of fish and seafood estimated by an FFQ was compared with intake a...

Introduction: Extensive hemolysis resulting in anuric renal failure is the main clinical sign of acute arsine poisoning. Plasmapheresis and exchange transfusion are recommended for patients with massive hemolysis. We report four cases of arsine exposure which demonstrate the effectiveness of continuous vein-venous hemodiafiltration and on-line hemodiafiltration for arsenic removal. Method: Bloo...