This master thesis describes the development of two methods of analysis for very polar pharmaceutical compounds in blood serum based on high performance liquid chromatography with multiple stage mass detection (LC-MS/MS). These methods are very selective and sensitive, but the response can be highly affected by coeluting serum constituents, which necessitates clean sample extracts and a good ch...

Spiropyrans are notable among different classes of photochromic compounds due to their large structural and electronic transformation upon isomerization. In order to parlay the electronic differences associated with the two isomeric forms into a materials based switch, the spiropyran ultimately requires a covalent attachment through a conjugated pathway. In this work a synthetic method was deve...

Marine macroalgae species from the polar regions were investigated for their importance as natural sources of volatile halogenated compounds released into the biosphere. Several different halogenated C1 to C4 hydrocarbons were identified and their release rates determined. The compounds contained mainly bromine and iodine, and form was the dominant compound released. Although an annual atmosphe...

A description is given of the development by collaborative study of two standardized methods for the determination of polar compounds in oils and fats by adsorption chromatography using silica minicolumns, and for quantification of polymerized triacylglycerols, oxidized triacylglycerols, and diacylglycerols in polar compounds by high-performance size-exclusion chromatography. The first procedur...

Aims: To examine the properties of hydrazide compounds shown to inhibit Mycobacterium tuberculosis. To identify properties that affect efficiency of bacterial inhibition. Study Design: Utilizing data from previous studies of compounds that inhibit Mycobacterium tuberculosis, then statistical and pattern recognition methods are applied to identify interrelationships. Place and Duration of Study:...

Extraction with water and ethanol are two common methods used to isolate secondary metabolites from Moringa oleifera. usually produces extracts rich in polar compounds, while extraction tends be better at isolating non-polar compounds. This study aimed carry out a systematic review related the comparative of metabolite content between aqueous The literature search process was carried on various...

Using the spin label method (ESR) it has been shown that biologically active, amphiphilic compounds (quaternary ammonium salts (AS) containing polar heads with single and double positive charge caused, at low concentrations, decrease fluidity of liposome membranes formed with egg yolk lecithin (EYL). At higher concentrations an increase in fluidity was observed. With compounds having a single p...