An important diagnostic criterion for social communication deficits in autism spectrum disorders (ASD) are difficulties in adjusting behavior to suit different social contexts. While the BTBR T+tf/J (BTBR) inbred strain of mice is one of the most commonly used mouse models for ASD, little is known about whether BTBR mice display deficits in detecting changes in social context and their ability ...

A recent study has found that carrying - not just holding - by human mothers has a specific calming effect on crying infants, inducing a coordinated physiological response that includes a reduction in heart rate. A similar response in mice has opened the door to elucidating the underlying neural mechanisms.

A traditional road diet design converts a four-lane two-way to three-lane consisting of two through lanes and center left turn lane. This paper introduces new application the in an urban corridor. Specifically, into two-lane with full-time parking both directions. The analyzed traffic impacts on corridor New Jersey Avenue, northwest, city Washington, District Columbia. included five signalized ...

BACKGROUND The stress that results from preterm birth, requisite acute care and prolonged physical separation in the Neonatal Intensive Care Unit (NICU) can have adverse physiological/psychological effects on both the infant and the mother. In particular, the experience compromises the establishment and maintenance of optimal mother-infant relationship, the subsequent development of the infant,...

Adolescents have different psychological conditions and spend a lot of time in boarding schools because they must live Islamic where many rules activities be followed. The research method used this case study is qualitative which consists survey, literature review, data analysis. A spatial approach taken to "read" the user space understanding spaces that trigger negative conditions. Negative we...

After catastrophic events in which people's survival has been threatened, as happened during the Khmer Rouge regime in Cambodia 1975-1979, some continue to suffer from painful mental symptoms. Surveys carried out in Cambodia based on Western diagnostic categories have found a high prevalence of posttraumatic stress disorder (PTSD), depression, and anxiety symptoms in the population. This study ...

In this issue, Limpitikul et al used the novel CRISPR interference (CRSPRi) strategy to suppress the expression of an arrhythmogenic mutant calmodulin (CaM) gene in human induced pluripotent cell-derived cardiomyocytes (iPSC-CM). This mutant CaM (D130G) is linked with long-QT syndrome (LQTS). The main LQTS mechanism is via a loss in Ca affinity of CaM, resulting in a loss of Ca-dependent inacti...