background: prostate cancer is one of the most widespread cancers in men and is fundamentally a genetic disease. identifying regulators in cancer using novel systems biology approaches will potentially lead to new insight into this disease. it was sought to address this by inferring gene regulatory networks (grns). moreover, dynamical analysis of grns can explain how regulators change among dif...

κ-casein is a glycosilated protein in mammalian milk that plays an essential role in the milk micelles. control of κ-casein expression reflects this essential role, although an understanding of the mechanisms involved lags behind that of the other milk protein genes. transcriptional regulation, a first mechanism for controlling the development of organisms, is carried out by transcription facto...

The unknown etiology of sarcoidosis, along with the variability in organ involvement and disease course, complicates effective treatment this disease. Based on recent studies, cellular inflammatory pathways involved granuloma formation are interest regarding possible new options, such as mechanistic (formerly mammalian) target rapamycin complex 1 (mTORC1) pathway, Janus kinase/signal transducer...

Yeast strains in which the Ras-cyclic AMP (cAMP) pathway is constitutively active are sensitive to heat shock, whereas mutants in which the activity of this pathway is low are hyperresistant to heat shock. To determine the molecular basis for these differences, we examined the transcriptional induction of heat shock genes in various yeast strains. Activation of heat shock genes was attenuated i...

The canonical Wnt-beta-catenin signaling pathway is important for a variety of developmental phenomena as well as for carcinogenesis. Here, we show that, in hippocampal neurons, NMDA-receptor-dependent activation of calpain induced the cleavage of beta-catenin at the N terminus, generating stable, truncated forms. These beta-catenin fragments accumulated in the nucleus and induced Tcf/Lef-depen...