INTRODUCTION Despite the undeniably positive effect on the quality of life of menopausal women, menopausal hormone therapy (HT) also has negative side-effects, which include, among others, thromboembolic complications. OBJECTIVE To assess the effect of a popular type of this therapy - transdermal HT on platelet hemostasis, which plays a significant role in intravascular coagulation. MATERIA...

There is a growing interest in transdermal delivery systems because of their noninvasive, targeted, and on-demand delivery of gene and drugs. However, efficient penetration of therapeutic compounds into the skin is still challenging largely due to the impermeability of the outermost layer of the skin, known as stratum corneum. Recently, there have been major research activities to enhance the s...

Drugs are administered by using different drug delivery systems. A number of drug delivery systems have evolved over the years. In the last 20 years TDDS (Transdermal drug delivery system) has been growing at a rapid pace. Now the micro needles are being developed as a novel drug delivery system. The micro needle skin patch system is also a drug delivery system, which will be used transdermally...

Comment This study showed an unexpectedly high rate (10%) of allergic contact dermatitis to transdermal hyoscine in healthy men treated for several months. Allergic contact dermatitis (type IV delayed hypersensitivity) was diagnosed by well established clinical criteria and was further confirmed by the absence ofany reaction to a placebo patch. Our results contrast with those of studies conduct...

UNLABELLED SUMMARY  AIM To evaluate the use of transdermal buprenorphine patches (Transtec®) in routine clinical practice. PATIENTS & METHODS A prospective, noninterventional, postmarketing study performed in the Czech Republic by 71 investigators in various clinical practice settings. Patients with chronic moderate-to-severe cancer pain, or chronic severe noncancer pain insufficiently cont...