The tissue kallikrein-kinin system has been recognized as a paracrine and/or autocrine hormonal system that regulates arterial pressure, renal hemodynamics, and electrolyte excretion. We have created a transgenic mouse model overexpressing human bradykinin B(2) receptor, and the mice developed lifetime hypotension. With this animal model, we further analyzed the potential role of B(2) receptors...

We have developed a transgenic animal model to investigate the effects of overexpression of rat prorenin on the cardiovascular system. Two transgenic rat lines were generated in which rat prorenin expression was directed to the liver by a human alpha1-antitrypsin promoter. Liver-specific expression was confirmed by RNase protection assay. Plasma prorenin concentrations in transgenic rats were i...

The meeting proved of great interest to those developing an animal model of chronic obstructive pulmonary disease (COPD). COPD is caused by cigarette smoking, evidenced by deterioration in lung function. Lung function is only rarely assessed in animal models. A cigarette smoke driven pathology should provide the best in vivo model for COPD. However, as lesions produced this way take 8-12 months...

objective(s) seed of cucumis sativus linn. is one of the herbal remedies has been traditionally used for diabetes mellitus treatment. we studied the effect of hydroalcoholic and buthanolic extract obtained from c. sativus seeds in a model of streptozotocin (stz)-induced diabetic (type i) rats. materials and methods normal and diabetic male wistar rats (stz, 60 mg/kg, intraperitoneal) were treat...

abstract unbalance using of chemical fertilizers cause decline the soil quality and fertility, environmental pollution and specially soil and water resources pollution. the use of animal manure is a replacement to chemical fertilizers. therefore, recognizing of demographic, technical-extensional and agronomic affect on farmer's decision making process to use of animal manure will have important...

objective: the aim of this study was to determine the protective effects of coriandrum sativum on acetic acid-inducedcolitis in rats. c. sativum (coriander) has long been used in iranian traditional medicine and its use as an anti-inflammatory agent is still common in some herbal formulations.  materials and methods: colitis was induced by intra-rectal administration of 2ml acetic acid 4% in fa...

the main aim of this research was to estimate the genetic and phenotypic parameters for productive and reproductive traits of esfahan native chickens. traits included body weights at hatch (bw1), 8 weeks of age (bw8), 12 weeks of age (bw12), and at sexual maturity (wsm)], age at sex maturity (asm), egg number (en), average egg weight (aew) in the first 12 weeks of production, and egg production...