BACKGROUND Central lymph node dissection (CND) has been proposed in the treatment of patients affected by papillary thyroid cancer (PTC) with clinically negative neck lymph nodes. The procedure allows pathologic staging of lymph nodes of the central compartment and treatment of the micrometastases. By comparing bilateral and unilateral thymectomy during total thyroidectomy with central lymph no...

The medical records of 84 patients submitted to extensive thyroidectomy from January 1991 to April 1995 were reviewed and the data was analyzed in order to verify a correlation between postoperative laboratories results and physical findings suggestive of hypocalcemia. It was verified that there was hypocalcemia in 51.2 percent of the patients, of which only 18.6 percent presented symptoms. It ...

The chromosome 22q11 deletion syndrome, which is synonymous with DiGeorge syndrome, is a congenital anomaly characterized by abnormal facies, congenital heart defects, hypoparathyroidism with hypocalcemia, and immunodeficiency. Neurological manifestations of the chromosome 22q11 deletion syndrome are variable, and include mental deficiency, speech disturbances, learning difficulties, attention ...

Hypocalcemia is presented in two forms, the less common clinical disease called milk fever and the more common form called subclinical hypocalcemia (SCH). Depending upon how it is defined and the frequency of blood sampling for diagnosis, SCH can affect 25 to 40% of primiparous and 45 to 80% of the multiparous cows. Cows with SCH have reduced dry matter (DM) intake, suppressed measures of innat...

BACKGROUND The purpose of this study was to determine the effectiveness of oral calcium plus vitamin D supplementation and to compare the effects of cholecalciferol versus calcitriol treatments on postoperative hypocalcemia. METHODS After total thyroidectomy with central neck dissection, 306 patients were divided into 4 groups according to "routine use versus on-demand use" and "cholecalcifer...

Under acute stress conditions in the rat, there is rapid and transient increase in circulating prolactin (PRL). This leads to an elevated expression of the long form of PRLR (PRLR-L) first in the hypothalamus and the choroid plexus. This increase in PRL is involved in the inhibition of stress-induced hypocalcemia and gastric erosion. In this study we used rat PRL and a PRLR morpholino-antisense...

OBJECTIVE To ascertain whether there are incremental risks associated with thyroid surgery in the elderly population. DESIGN Prospective analysis of a consecutive single-surgeon series of patients undergoing thyroid surgery at an academic health center. SETTING Tertiary care health center. PATIENTS The study included patients aged 21 to 35 years and patients 65 years and older who underwe...

HYPOTHESIS Age, postoperative serum parathormone (PTH) level, and preoperative serum 25-hydroxyvitamin D(3) (25-OHD) level predict postoperative hypocalcemia after total thyroidectomy. DESIGN Prospective clinical trial. SETTING Tertiary referral center. PATIENTS One hundred thirty patients with nontoxic multinodular goiter. Patients were divided into 2 groups according to the postoperativ...

N-(3-[2-Chlorophenyl]propyl)-(R)-alpha-methyl-3-methoxybenzylamine (NPS R-568) is an orally active compound that activates Ca(2+) receptors on parathyroid cells and rapidly suppresses plasma levels of parathyroid hormone (PTH) and Ca(2+) (ED(50), 1 and 10 mg/kg, respectively). We now show that increased calcitonin secretion contributes to NPS R-568-induced hypocalcemia. In parathyroidectomized ...

Although stridor is a common respiratory symptom associated with upper respiratory diseases, yet its relation with hypocalcemia is not widely appreciated. The mechanism of hypocalcemia in causing stridor might be a collapsing of larynx most likely caused by decalcifi cation due to hypocalcemia. Vitamin D defi ciency causes a reduction in serum calcium, which stimulates the production of extra P...