Since next-generation sequencing (NGS) technique was adopted into clinical practices, revolutionary advances in diagnosing rare genetic diseases have been achieved through translating genomic medicine into precision or personalized management. Indeed, several successful cases of molecular diagnosis and treatment with personalized or targeted therapies of rare genetic diseases have been reported...

Precision medicine is based on a simple precept that deep information about an individual patient can be used to guide his or her healthcare. In the not-too-distant future, clinicians may have point-of-care access to an individual’s entire genome, dense data captured from wearable devices, and informatics tools that aggregate data from clinical experience to allow for real-time decision support...

This paper describes research investigating the significance of physical experience and materiality in creative digital visual art and design practice. Findings are presented from a recent phenomenological study, which indicates the ways in which memory of lived experience informs creative cognition and feeds the imagination. The importance of physical engagement with the world, through the sen...

Analyses of nucleotide patterns in coding regions of prokaryotes have revealed that selection acts on DNA and RNA stability and on translational accuracy. Here we examine the positions of mononucleotide repeats within microbial genes and detect a pervasive bias in the locations of these disruptive elements that becomes more pronounced with increases in repeat length. We argue that, because thes...

In this paper, some possible ways of translating semi-compositional constructions with the help of a computer are presented. Two possible methods are proposed: first, the one based on lexical functions, and, second, the statistical-based one making use of lexico-semantic relations between the noun and the verb. The application of both methods in machine translation would yield higher accuracy o...

This paper describes a method for improving the comprehensibility, accuracy, and generality of reactive plans. A reactive plan is a set of reactive rules. Our method involves two phases: (1) formulate explanations of execution traces, and (2) generate new reactive rules from the explanations. The explanation phase involves translating the execution trace of a reactive planner into an abstract l...

We present a speech-to-speech translation system for notebook PC's that helps oral communication between Japanese and English speakers in the various situations in the travel abroad. Due to the high accuracy of the compact continuous speech recognition engine and our lexicalized grammar approach to machine translation that utilizes corpus but is oriented to model general linguistic phenomena as...

This paper describes a method for improving the comprehensibility, accuracy, and generality of reactive plans. A reactive plan is a set of reactive rules. Our method involves two phases: (1) formulate explanations of execution traces, and (2) generate new reactive rules from the explanations. The explanation phase involves translating the execution trace of a reactive planner into an abstract l...

Traditional recommender system evaluation focuses on raising the accuracy, or lowering the rating prediction error of the recommendation algorithm. Recently, however, discrepancies between commonly used metrics (e.g. precision, recall, root-mean-square error) and the experienced quality from the users’ have been brought to light. This project aims to address these discrepancies by attempting to...