PurposeSevere heart valve disease is a rare indication for transplant. We evaluated outcomes after transplant vs. other indications at the national level.MethodsAdult patients undergoing first-time heart-only 2005-2021 were identified using UNOS/OPTN database. compared post-transplant of receiving transplants diagnoses. Survival was Kaplan-Meier curves and log-rank test, as well by multivariabl...

NHS Blood and Transplant; Imperial College Healthcare NHS Trust, London; University College Hospitals NHS Trust; Serious Hazards of Transfusion, NHS Blood and Transplant, Manchester/TTF member; Royal Hospital for Sick Children, Glasgow; NHS Blood and Transplant, Manchester; St. Mary’s Hospital, Manchester/University of Manchester; Royal Brompton Hospital, London; Mater Research Institute, Unive...

Homozygous mutations in cytochrome b-245 chaperone 1 (CYBC1) have been recently described as causing recurrent infections and inflammatory disease an Icelandic cohort a patient from Saudi Arabia, by destabilising the dimerisation of gp91phox with p22phox, manifesting phenotypic chronic granulomatous (CGD). Haematopoietic stem cell transplantation is treatment choice CGD, though experience this ...

Renal dysfunction frequently occurs in liver transplant recipients and is associated with increased morbidity and mortality. BK virus is a human polyoma virus that reactivates during immunocompromised states and is a known cause of renal allograft dysfunction in renal transplant recipients. However, BK nephropathy of native kidneys is rare in non-renal transplant recipients. There is no publish...

OBJECTIVE People tend to overestimate the impact that future events will have on their quality of life. In the case of a medical treatment like kidney transplant, this should result in biased predictions--overestimates of how much the transplant will benefit quality of life. The authors surveyed kidney transplant patients, both before and after transplant, to test whether they would overestimat...

PurposeLung transplant patients are at risk of fungal infections post-transplant and require anti-fungal prophylaxis (AFP). However, utilization duration these agents can be limited by adverse effects. The purpose this evaluation was to assess the tolerability AFP post-lung a large academic medical center.MethodsThis single-center retrospective review included lung transplanted from August 2017...

evidences from many studies suggested a polymerase chain reaction (pcr) as a valuable method for diagnosing infectious disease in the transplant recipients. we used this method for detection of toxoplasma, gondii and human cytomegalovirus in blood specimens from patients after bone marrow or kidney transplantation. dna of both infectious agents were detected using two separate sets of nested pr...

New immunosuppressive therapies that improve long-term graft survival are needed in kidney transplant. Critical Path Institute’s Transplant Therapeutics Consortium received a qualification opinion for the iBOX Scoring System as novel secondary efficacy endpoint transplant clinical trials through European Medicines Agency’s of methodologies drug development. This is first qualified any indicatio...