BACKGROUND Administrative data are increasingly being used to assess outcomes in kidney transplant recipients. OBJECTIVE To assess the validity of transplant data in healthcare administrative databases compared to the reference standard of information collected directly from transplant centres. DESIGN Retrospective cohort study. SETTING One of three major transplant centres in Ontario (To...

Background: Solid organ transplant recipients develop cutaneous malignancies at a higher rate and with a more aggressive clinical course when compared to the general population. Due to a lack of current information within the transplant literature, we sought to assess the clinical course, treatment and outcomes of metastatic skin cancer in solid organ transplant recipients. Methods: Medical rec...

Chronic graft-versus-host disease (cGvHD) is associated with functional immunodeficiency and an increased risk of opportunistic infections in allogeneic bone marrow transplantation (BMT). We used a parent to F1 model of allogeneic BMT to test the hypothesis that cGvHD leads to impaired antigen-specific antiviral immunity and compared BM transplant recipients with cGvHD to control groups of allo...

Human herpesvirus 6 (HHV-6) is a ß-herpesvirus that is characteristically T-lymphotropic. It is regarded to be a major pathogen in transplant recipients. Very little is known about the prevalence of HHV-6 in Saudi transplant recipients . The aim of the current study was to determine the HHV-6 antibodies (IgM and IgG) and viral DNA in Saudi renal transplant recipients. The study was conducted a ...

We examined mortality and recurrence of hepatocellular carcinoma (HCC) among 106 transplant candidates with cirrhosis and HCC who had a potential living donor evaluated between January 1998 and February 2003 at the nine centers participating in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL). Cox regression models were fitted to compare time from donor evaluation and ...

BACKGROUND Polyomavirus reactivation can cause significant morbidity in solid organ transplant recipients, particularly BK virus (BKV) in kidney transplant patients. Less is known about dynamics of John Cunningham virus (JCV) in nonkidney organ transplant patients. METHODS We examined the frequency of urinary shedding of polyomaviruses BKV and JCV and their relationship to creatinine clearanc...

• BACKGROUND Many benefits and adverse effects of positioning are related to changes in ventilation and perfusion. A number of unique factors related to the allograft make the effects of positioning difficult to determine in single-lung transplant recipients. • OBJECTIVES To determine the effect of 3 body positions (supine, lateral with allograft lung down, and lateral with native lung down) on...

Viral infections are a major cause of morbidity and even mortality in solid organ transplant recipients. This article reviews key aspects of infections in solid organ transplant recipients from respiratory viruses, such as influenza, polyomavirus, erythrovirus B19 and measles.

Background and Purpose: Invasive candidiasis (IC) is a significant cause of morbidity and mortality in patients with hematologic disorders and bone marrow transplant recipients. Rapid, specific and sensitive test for the timely accuracy in immunocompromised patients to reduce mortality rates and prevent IC progress is necessary. We established a real-time PCR assay on blood for the diagnosis an...

BACKGROUND To date there are no data on the effects of lung transplantation on diaphragmatic function in patients with end stage chronic obstructive pulmonary disease (COPD). It is not known whether the relation between the transdiaphragmatic pressure (PDI) and lung volume is altered in recipients after transplantation as a result of changes in diaphragmatic structure caused by chronic hyperinf...