Although heart failure is managed medically most of the time, heart transplantation is still last resort for selected end-stage heart failure patients with noncompaction cardiomyopathy. Presently described for the first time is case of pediatric patient with noncompaction cardiomyopathy who was initially referred to our hospital for heart transplant but underwent PDA repair and improved clinica...

OBJECTIVE This study evaluated the diagnostic performance of two methods for the detection of influenza virus in immunocompromised transplant patients. METHODS A total of 475 respiratory samples, 236 from patients in a hematopoietic stem cell transplantation program and 239 from kidney transplant patients, were analyzed by a direct fluorescence assay and the Centers for Disease Control real-t...

AIM To compare the differential immune T cell subset composition in patients with acute T cell-mediated rejection in the kidney transplant with subset composition in the absence of rejection, and to explore the association of their respective immune profiles with kidney transplant outcomes. METHODS A pilot cross-sectional histopathological analysis of the immune infiltrate was performed using...

The ability of the model for end-stage liver disease (MELD) score to accurately predict death among liver transplant candidates allows for evaluation of geographic differences in transplant access for patients with similar death risk. Adjusted models of time to transplant and death for adult liver transplant candidates listed between 2002 and 2003 were developed to test for differences in MELD ...

CDKN2A is a proven and validated biomarker of ageing which acts as an off switch for cell proliferation. We have demonstrated previously that CDKN2A is the most robust and the strongest pre-transplant predictor of post-transplant serum creatinine when compared to "Gold Standard" clinical factors, such as cold ischaemic time and donor chronological age. This report shows that CDKN2A is better th...

BACKGROUND AND OBJECTIVES Few studies have examined health literacy in patients with end stage kidney disease. We hypothesized that inadequate health literacy in a hemodialysis population is common and is associated with poorer access to kidney transplant wait-lists. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS We enrolled 62 Black and White maintenance hemodialysis patients aged 18 to 75. W...

Objective To compare the incidence of oropharyngeal candidiasis (OC), or thrush, in renal transplant recipients receiving nystatin versus no antifungal prophylaxis. Methods This was a single-center, retrospective, non-inferiority study adult (RTRs) who received for 30 days OC prophylaxis (nystatin group) therapy (No PPX group). The primary outcome within 3 months post-transplant. Secondary outc...

OBJECTIVES Despite the demonstration of oxidative stress in patients with end-stage renal disease, the oxidative status during and after a renal transplant are not completely understood. Hepatocyte growth factor is reported to act as an endogenous factor against oxidative stress. The aim of this study was to evaluate the pattern of changes in plasma oxidative status and hepatocyte growth factor...

Results: Older patient age at the time of transplant was a significant factor favorably affecting patient survival (P .031). Trends toward better survival rates were observed in those transplants performed more recently (P .063), in those patients with greater body weight (P .084), in those not hospitalized at the time of transplant (P .14), and in those without concomitant liver failure (P .12...

Post-transplant lymphoproliferative disease (PTLD) describes a heterogenous group of lymphoproliferative diseases, occurring as a result of uncontrolled B cell proliferation in the context of post-transplant immunosuppression. The incidence depends on the type of transplant and immunosuppression used; the median time to onset is shorter for recipients of stem cell transplants (2 months) than th...