Brain-derived neurotrophic factor (BDNF) and its receptors tyrosine kinase B (trkB), and cyclic adenosine monophosphate response element binding protein (CREB) have been suggested as the neurobiological risk factors causing depressive disorder. Serotonin (5-hydroxytryptamine, 5-HT) plays an important role in the pathogenesis of depression. We in-vestigated the effect of treadmill exercise on so...

To examine emotion regulation in later life, we contrasted the modified hedonic treadmill theory with developmental theories, using hassles and uplifts to assess emotion regulation in context. The sample was 1,315 men from the VA Normative Aging Study aged 53 to 85 years, who completed 3,894 observations between 1989 and 2004. We computed three scores for both hassles and uplifts: intensity (ra...

The aim of this study was to compare the cardiometabolic demands of running on a curved non-motorized treadmill (cNMT) with overground (OVR) and motorized treadmill (MOT) running. Fourteen trained male (n = 7) and female (n = 7) runners ([Formula: see text] 56.6 ± 4.0 mL.kg-1.min-1) participated in the study. Each experimental session consisted of 5 × 6-min bouts of running at progressively hig...

OBJECTIVE To compare the effect of body-weight-supported treadmill training (BWSTT) and full-body-weight treadmill training (FBWTT) on patients with knee osteoarthritis (OA). METHODS Design was Randomized controlled trial. Patients with knee osteoarthritis (n = 30; mean age, 76.0±7.5 y) were randomly assigned to BWSTT or FBWTT group. All patients performed 20 min walking exercise twice a week...

Materials and methods Ninety-day-old female Wistar rats were divided into three groups: exercised-control (EC; n=5), high intensity exercised-diabetic (HIED=high intensity training, 80% of the maximum speed in the stress test; n=4) and low intensity exercised-diabetic (LIED=low Intensity training, 40% of the maximum speed in the stress test; n=6). The diabetes was induced in the rats by adminis...

Maximum exercise testing using treadmill walking and cycle ergometry was compared in 40 male patients who had suffered a myocardial infarction in the preceding twelve months. Maximum oxygen uptake was on average 17% greater in the treadmill than the cycle test and maximum heart rate was also higher, but the rate pressure product (RPP) was similar due to a higher blood pressure in the cycle ergo...