We thank Brasky et al. for their review (Brasky et al., 2016) of our meta-analysis on the association between NSAID use and risk of endometrial cancer (Verdoodt et al., 2016). We welcome the additional information on two of their studies, and the discussion points they have raised, which are valuable contributions to the topics discussed in our meta-analysis. Below we respond to the issues rais...

OBJECTIVE To assess the safety and efficacy of a low-dose magnesium sulfate regimen for the management of eclampsia in Indian women. METHODS A loading dose consisting of 3g of magnesium sulfate intravenously plus 5g intramuscularly (2.5g in each buttock) was followed by 2.5g intramuscularly every 4hours, for 24hours beyond the last seizure. In a first phase, which spanned 2001 and 2002, the r...

DESCRIPTION Update of the 1996 U.S. Preventive Services Task Force (USPSTF) recommendation on aspirin prophylaxis in pregnancy. METHODS The USPSTF reviewed the evidence on the effectiveness of low-dose aspirin in preventing preeclampsia in women at increased risk and in decreasing adverse maternal and perinatal health outcomes, and assessed the maternal and fetal harms of low-dose aspirin dur...

The current study investigated the efficacy and safety of olmesartan medoxomil in children with hypertension, defined as systolic blood pressure measured at or above the 95th percentile (90th percentile for patients with diabetes, glomerular kidney disease, or family history of hypertension) for age, gender, and height while off any antihypertensive medication. The active treatment phase was co...

Introduction: Brachytherapy is one type of internal radiation therapy where radiation sources, which are usually encapsulated, are placed as close as possible to the tumor site or inside the patient's body. In this technique, it is important to determine dose distribution around the brachytherapy capsule to create optimal treatment plant. In this way, dosimetric parameters are...

In type 1 diabetes mellitus, the impaired testosterone synthesis in testes leads to androgen deficiency. The long-term application of high gonadotropin doses for its correction decreases sensitivity luteinizing hormone/human chorionic (LH/hCG) receptors Leydig cells endogenous gonadotropins. aim this work was study effect a 3-day treatment male Wistar rats with streptozotocin 5-amino- N-tert -b...

PURPOSE Historically, treatment of malignant surface lesions has been achieved with linear accelerator based electron beams or superficial x-ray beams. Recent developments in the field of brachytherapy now allow for the treatment of surface lesions with specialized conical applicators placed directly on the lesion. Applicators are available for use with high dose rate (HDR)(192)Ir sources, as w...

We describe a patient with acute cardiogenic shock due to cardiac involvement in idiopathic hypereosinophilic syndrome (Löffler endocarditis). At the echocardiography, there was a huge mass in the left ventricular cavity, resulting in inflow- and outflow tract obstruction. The posterior leaflet of the mitral valve apparatus was completely embedded in a big (organized) thrombus mass. The patient...

Hematide is a synthetic peptide-based, pegylated erythropoiesis stimulating agent in clinical development for treatment of anemia. To support chronic clinical dosing requirements, a 9-month repeat dose IV monkey safety study was undertaken. Animals received 0, 0.2, 2 or 20 mg/kg hematide IV every three weeks for nine months followed by a 14-week recovery. Hematide administration was associated ...

PURPOSE The purpose of this study is to evaluate the dosimetric uncertainty associated with Gafchromic™ (EBT3) films and establish a practical and efficient film dosimetry protocol for Stereotactic Radiosurgery (SRS) and Stereotactic Body Radiotherapy (SBRT). METHOD AND MATERIALS EBT3 films were irradiated at each of seven different dose levels between 1 and 15 Gy with open fields and standar...