The Biomarker Strategy Design has been proposed for trials assessing the value of a biomarker in guiding treatment in oncology. In such trials, patients are randomised to a control arm, receiving the standard chemotherapy treatment, or a biomarker-directed treatment arm, when biomarker status is used to guide treatment. The randomised groups are then compared, often using a noninferiority test ...

Invasive cervical cancer is rare during a pregnancy, even though it is one of the most frequently diagnosed neoplasias during that time. It is noted that around 30% of women diagnosed with cervical cancer are of reproductive age. This means that up to 3% of cases of cervical cancer are found in pregnant women or those who are in the post-birth period. A cervicovaginal Pap smear is performed as ...

In order to improve the quality of life and to prevent chronic complications related to diabetes mellitus, intensive lifestyle modification and proper medication are needed from the early stage of diagnosis of type 2 diabetes mellitus (T2DM). When using the first medication for diabetic patients, the appropriate treatment should be selected considering the clinical characteristics of the patien...

OBJECTIVES Primary surgery in patients with complete unilateral and bilateral cleft lip and palate restricts transverse and sagittal maxillary growth. Additional surgical maxillary advancement might become necessary after completion of growth. The aim of this study was to determine the extent of maxillary deficiency at an early stage during the transitory dentition, and to identify factors that...

chamomile (matricaria chamomilla l.) is one of the most important medicinal plants in iran. the main objective of this study was to determine the effects of organic nutrients on the yield and oil content of chamomile. the experiment was conducted in the spring of 2010. the treatment groups consisted of vermicompost (0, 5, 10, 15 and 20 tons/ha) and the aminol forte sprays (no spraying or contro...

BACKGROUND Gait recovery is very important to stroke survivors to regain their independence in activity of daily life. OBJECTIVE This study aimed to investigate the effects of virtual reality (VR) coupled body weight support treadmill training (BWSTT) on pelvic control at the early stage of stroke. METHODS Kinematic and kinetic changes of pelvic motion were evaluated by a 3D gait analysis s...

In order to investigate drought stress and plant density the yield, yield components and protein of spotted bean grain (cultivar Talash), an experiment was carried out as split plots in randomized complete blocks with three replications in Yasouj, in 2012. Factors of the test including irrigation in three levels; without stress (control treatment), water stress in vegetative stage (interrupting...

Weather Information processing and knowledge extraction is one of the challenging applications of data mining. This process area requires authenticated and intelligent processing to obtain accurate information from the knowledge set. In this work, an intelligent clustering mechanism is defined to acquire such information. This neuro-fuzzy based model is applied on raw dataset defined with vario...

Pressure ulcers are common among selected patient populations. Early therapeutic intervention may result in a decrease in the number of ulcers that progress to a later stage. The efficacy of specific skin creams for the treatment and prevention of early stage pressure ulcers has not previously been evaluated. We compared the healing rates of paired, early stage pressure ulcers treated with eith...

Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer-related deaths in the world. The Barcelona Clinic Liver Cancer (BCLC) classification has recently emerged as the standard classification system for clinical management of patients with HCC. According to the BCLC staging system, curative therapies (resection, transplantation, and percutaneous abl...