This paper introduces a multiscale analysis based on optimal piecewise linear approximations of time series. An optimality criterion is formulated and on its base a computationally effective algorithm is constructed for decomposition of a time series into a hierarchy of trends (local linear approximations) at different scales. The top of the hierarchy is the global linear approximation over the...

The study of cardiovascular disease has increased both in its scope and pace during the last decade. Included amongst the circumstances which have contributed to these changes are the recruitment to the specialty of younger workers on leaving the Fighting Services, the provision of greater facilities for research work, and the addition of newer instruments and equipment in the investigation of ...

The letter written by Heinze (1) has serious shortcomings. Heinze wrote that There is not a single study of healthy men from any fertility center or sperm bank that has reported a decline in sperm counts in the United States. This is not true. A number of such studies exist. Leto and Frensilli (2) documented a decline in sperm counts in potential sperm donors from all over the United States in ...

The discovery of classical and quantum completely integrable systems led to an increase in interest in the theory of Abelian functions in theoretical physics and applied mathematics. This area was considered traditionally as a field of pure mathematics. This new trend makes it necessary to reconsider classical results in the area from the point of view of modern applications. In this paper we c...

Biomedical knowledge is one of the pivots of e-health research. This is oriented to the discovery and management of customized and adaptive biomedical information concerning the assisted users, organizational workflows, and living situations. Signal processing in e-health is deployed by means of layers of distributed components from smart sensors to mathematical models in computing provider cen...

InfoSleuth is an agent-based system that can be configured to perform many different information management activities in a distributed environment. InfoSleuth agents provide a number of complex query services that require resolving ontology-based queries over dynamically changing, distributed, heterogeneous resources. These include distributed query processing, locationindependent single-resou...

One established trend in electronics is micromation. Many digital devices are becoming smaller and many new functionalities are built up with various sensors. Sensors and sensor networks have been widely applied in monitoring, detecting and tracking, and are especially useful for applications in hazardous or hostile environments. Location discovery is a fundamental function in sensor networks. ...

InfoSleuth is an agent-based system that can be configured to perform many different information management activities in a distributed environment. InfoSleuthTM agents provide a number of complex query services that require resolving ontology-based queries over dynamically changing, distributed, heterogeneous resources. These include distributed query processing, locationindependent single-res...

Summarizing the status of drugs in the market and examining the trend of drug research and development is important in drug discovery. In this study, we compared the drug targets and the market sales of the new molecular entities approved by the U.S. Food and Drug Administration from January 2000 to December 2009. Two networks, namely, the target-target and drug-drug networks, have been set up ...