BACKGROUND γ-Aminobutyric acid-B receptor antibodies (GABA(B)R-ab) were recently described in 15 patients with limbic encephalitis (LE), associated with small-cell lung cancer (SCLC) or with concurrent glutamic acid decarboxylase (GAD) antibodies. We analyzed the frequency of GABA(B)R-ab in 147 patients with LE or neurologic syndromes associated with GAD-ab. METHODS We examined the presence o...

Background: Plasma membrane of the spermatozoa interacts with and is altered by abundant seminal PDC-109 present in their immediate milieu in vivo with damaging effect in a time- and concentration- dependent manner. Therefore we hypothesized that sequestration of detrimental protein from ejaculates would be beneficial for cryopreservation of sperm cells. To this aim we evaluated the effect of s...

introduction: intravenous drug users as a serious health problem in communities have economical and social effects as well as health and hygienic complications. viral infections may be transmitted through drug injection by shared syringes among users. the aim of this study has been to determine the relative frequency of hbv, hcv and hiv infection’s markers as epidemiological data in ahvaz. mate...

objective: due to the increased prevalence of thyroid dysfunction in subjects with type 2 diabetes and also this fact that antibodies could potentially identify subjects at risk of thyroid dysfunction, this study was conducted to investigate thyroid autoimmunity in type 2 diabetic patients. material and methods: among patients referred to yazd diabetes research center, 4000 type 2 diabetic pati...

The knowledge about dietary habits and their influence in the development of autoimmune thyroid disease is insufficient. The aim of this study was to analyse the association of dietary factors and plasma thyroid peroxidase antibodies (TPO-Ab) and/or thyroglobulin antibodies (Tg-Ab). The study enrolled 1887 participants originating from the South Croatia. Participants with elevated plasma TPO-Ab...

Metal-ion and sequence dependent changes in the stacking interactions of bases surrounding abasic (AB) sites in 10 different DNA duplexes were examined by incorporating the fluorescent nucleotide probe 2-aminopurine (2-AP), opposite to the site (AB-APopp) or adjacent to the site (AB-APadj) on either strand. A detailed study of the fluorescence emission and excitation spectra of these AB duplexe...

BACKGROUND AND PURPOSE The differences in the characteristics of thymus histology, coexisting autoimmune diseases and related autoantibodies between anti-muscle-specific receptor tyrosine kinase (MuSK)-antibody (Ab)-positive myasthenia gravis (MG) patients, and anti-acetylcholine receptor (AChR)-Ab-positive MG patients are not clearly defined. METHODS The types of thymus histology, coexisting...

Among the large spectrum of autoantibodies (Ab) detected in systemic lupus erythematosus (SLE), anti-dsDNA Ab have been used to diagnose and assess disease activity for more than 60 years. Anti-dsDNA Ab are often associated with anti-nucleosome Ab, and in clinical practice combining both is helpful for diagnosis, prognosis, and as biomarkers to monitor response to treatment, especially when usi...

NMR studies of amyloid b-peptides (Ab) in aqueous solution provide a novel way in which to characterize the apparent Alzheimer’s disease-related conformational polymorphism of Ab. In the aqueous medium, neither of the polypeptides Ab(1–40) or Ab(1–42) (both of which contain a methionine sulfoxide at position 35) is folded into a globular structure, but they both deviate from random coil behavio...

icholas M. Boers Department of Computing Science, University of Alberta, Edmonton, AB, Canada David Chodos Department of Computing Science, University of Alberta, Edmonton, AB, Canada Pawel Gburzynski Department of Computing Science, University of Alberta, Edmonton, AB, Canada Lisa Guirguis Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada Jianzhao Hua...