1. Thygesen K, Alpert JS, White HD. Universal definition of myocardial infarction. J Am Coll Cardiol 2007;50:2173–95. 2. Lim CCS, van Gaal WJ, Testa L, et al. With the “universal definition,” measurement of creatine kinase-myocardial band rather than troponin allows more accurate diagnosis of periprocedural necrosis and infarction after coronary intervention. J Am Coll Cardiol 2011;57:653–61. 3...

Strategies to rule out myocardial infarction (MI)2 in the emergency department include stress test echocardiography, electrocardiography, and assessment of cardiac biomarkers such as troponin I and T (1). The potential for new high-sensitivity cardiac troponin testing to simplify and expedite these rule-out protocols is of great interest. Is all the hype justified? Or are we placing unreasonabl...

OBJECTIVES To determine the incremental value of clinical data, troponin T, ST segment monitoring, and heart rate variability for predicting outcome in patients with non-ST elevation acute coronary syndromes. METHODS Prospective cohort study of 304 consecutive patients. Baseline clinical and electrocardiographic data were recorded, serial blood samples were obtained for troponin T assay, and ...

Case Report A 43-year-old healthy woman came to the emergency department complaining of a dull ache in her left chest, which radiated to her left shoulder. The pain was minimal but constant and unaffected by exertion or rest. She had no associated diaphoresis, nausea, or vomiting. The patient did not smoke and did not have hypertension, diabetes, or a family history of cardiac disease. Her low-...

Familial hypertrophic cardiomyopathy (HCM) is caused by mutations in at least 8 contractile protein genes, most commonly b myosin heavy chain, myosin binding protein C, and cardiac troponin T. Affected individuals are heterozygous for a particular mutation, and most evidence suggests that the mutant protein acts in a dominant-negative fashion. To investigate the functional properties of a trunc...

background polypeptide hormone leptin suppresses inflammation in the heart muscle and protects heart from diseases. the purpose of this study is to evaluate the relationship between leptin and troponin serum levels with cardiac involvement in patients with major beta thalassemia. materials and methods in this cross-sectional study, 70 children with major thalassemia were selected. two ml blood ...

Fechtrup C, Ostermann H, van de Loo J. Prothrombin activation fragment 112 and thrombin-antithrombin III complexes in patients with angina pectoris: relation to the presence and severity of coronary atherosclerosis. Thromb Haemostasis 1993;70:550–3. 9. Merlini PA, Bauer KA, Oltrona L, Ardissino D, Cattaneo M, Belli C, et al. Persistent activation of coagulation mechanism in unstable angina and ...

BACKGROUND/AIM To evaluate pregnancy-associated plasma protein A (PAPP-A), ischemia-modified albumin (IMA), procalcitonin, and troponin I levels as diagnostic markers of acute coronary syndrome in patients admitted to the emergency department. MATERIALS AND METHODS The serum PAPP-A, IMA, procalcitonin, and troponin I levels were measured in 100 patients with acute coronary syndrome admitted t...

Acute myocardial infarction (AMI) was defined based on clinical findings, ECG abnormalities and cardiac enzymes. However with sensitive marker such as troponin the definition has been refined. In this study two cut-off values of troponin T (0.03ng/mL and 0.1ng/mL) were compared with the final diagnosis of AMI made by the physician. This was a retrospective study to determine the efficiency of c...