Electron microscopy of tissues from two necropsies carried out in the Sudan on patients with Ebola virus infection identified virus particles in lung and spleen, but the main concentrations of Ebola particles were seen in liver sections. Viral precursor proteins and cores were found in functional liver cells, often aligned in membrane-bound aggregations. Complete virions, usually found only ext...

Tubular epithelial loss has been shown to be responsible for the formation of atubular glomeruli leading to nephron decomposition and interstitial fibrosis in obstructive uropathy. Cells undergoing apoptosis and autophagic cell death play an important role in this process, yet the mechanisms are not fully understood. In this study, we aimed to inv...

The burst of reactive oxygen species (ROS) during reperfusion of ischemic tissues can trigger the opening of the mitochondrial permeability transition (MPT) pore, resulting in mitochondrial depolarization, decreased ATP synthesis, and increased ROS production. Rapid recovery of ATP upon reperfusion is essential for survival of tubular cells, and inhibition of oxidative damage can limit inflamma...

Electrical excitability is an essential feature of cardiomyocytes and the homogenous propagation of the action potential is guaranteed by a complex network of membrane invaginations called the transverse-axial tubular system (TATS). TATS structural remodelling is a hallmark of cardiac diseases and we demonstrated that this can be accompanied by electrical defects at single T-tubular level. Usin...

Virtual endoscopy is a promising medical application of volume visualization techniques. A virtual endoscopy system requires high quality and perspective projection rendering, as well as real-time navigation. In this paper the generation of a cylindrical structure for tubular shaped organs (i.e. colon, aorta) is presented. This structure represents an approximation of the real organ. The cylind...

We discuss the problem of the optimal design of a micro-tubular fuel cell applying an inverse homogenization technique. Fuel cells are extremely clean and efficient electrochemical power generation devices, made up of a cathode/electrolyte/anode structure, whose energetic potential has not being fully exploited in propulsion systems in aeronautics due to their low power densities. Nevertheless,...

An 18-year-old young man with no medical history presented at the emergency department with nausea, vomiting and pain in the right iliac fossa and the periumbilical region. Blood analysis was normal except for an elevated C-reactive protein (CRP) of 64 mg/L. High frequency gray-scale sonogram was performed and showed a normal presentation of the appendix. A tubular hypo-echogenic structure (len...

The energetics and photodynamics of carbonaceous molecular bearings with discrete molecular structures were investigated. A series of supramolecular bearings comprising belt-persistent tubular cycloarylene and fullerene molecules accepted photonic stimuli to afford charge-separated species via a photoinduced electron transfer process. The energy conversion processes associated with the photoexc...