primary and secondary malignant central nervous system (cns) tumors are devastating invasive tumors able to give rise to many kinds of differentiated tumor cells. glioblastoma multiform (gbm), is the most malignant brain tumor, in which its growth and persistence depend on cancer stem cells with enhanced dna damage repair program that also induces recurrence and resists current chemo- and radio...

background:chemotherapy-induced neutropenia as a major toxicity of systemic chemotherapy is commonly associated with substantial mortality and morbidity, and thus identifying its determinants is necessary. this study was undertaken to identify main risk factors of severe neutropenia following adjuvant chemotherapy treatment in a community-based population of patients with cancer in semnan, iran...

cancer immunotherapy (passive or active) involves treatments which promote the ability of the immune system to fight tumor cells. several types of immunotherapeutic agents, such as monoclonal antibodies, immune checkpoint inhibitors, non-specific immunomodulatory agents, and cancer vaccines are currently under intensive investigation in preclinical and clinical trials. cancer vaccines induce pe...

background: giant cell tumor is a benign but locally aggressive bone neoplasm which uncommonly involves the skull. giant cell tumor (gct) of the sphenoid bone is relatively rare. in this report, we describe a tumor of the greater wing of left sphenoid bone. case presentation: a 31-year-old female was presented with headache, proptosis and diplopia of her left eye. cranial magnetic resonance ima...

Introduction: Acoustic transient cavitation is the primary mechanism of sonochemical reaction and has potential use for tumor treatment. In this study, the in vivo anti-tumor effect of simultaneous dual-frequency ultrasound at low-level intensity (ISATA < 6 W/cm2) was investigated in a spontaneous murine model of breast adenocarcinoma in Balb/c mice. Materials and Methods: Forty tumor bearing m...

a desmoplastic small round cell tumor is a malignant tumor of the abdominal and pelvic cavities. this tumor involves serosal surfaces such as the peritoneum, pleura, and scrotum. in this case report a 28-year old male presented with a desmoplastic small round cell tumor located in the abdomen along with urological symptoms. when the diagnosis was completed, the patient’s tumor had metastasized ...

introduction: thermal ablation by microwave (mwa) has proven efficacy in treatment of primary and metastatic cancers. soft tissue tumors could be ablated completely using mwa. however, bony tissue metastasis particularly spinal vertebral metastasis ablation has not reported yet. case presentation: a 50 year old male patient with primary diagnosed colon cancer undergone surgical resection of tum...

how to cite this article: talebian a, goudarzi rm, mohammadzadeh m , mirzadeh as. vincristine-induced cranial neuropathy. iran j child neurol. 2014 winter; 8(1):66-68.   abstract vincristine (vcr) is a vinca alkaloid that is used for treatment of many malignancies. the vinca alkaloids are neurotoxic, usually causing a peripheral neuropathy, but cranial neuropathies are rare as side effects.  de...

micrornas are 19-22 nucleotide rnas involved in such important processes as development, proliferation, differentiation and apoptosis. different mirnas are uniquely expressed in lymphoid t cells, and play a role indevelopment and differentiation of various subtypes by targeting their target genes. recent studies have shown that aberrant mirna expression may be involved in t cell leukemogenesis ...