Recycling endosomes are generally thought to play a central role in endocytic recycling, but recent evidence has indicated that they also participate in other cellular events, including cytokinesis, autophagy, and neurite outgrowth. Rab small GTPases are key regulators in membrane trafficking, and although several Rab isoforms, e.g., Rab11, have been shown to regulate recycling endosomal traffi...

Kasus Tuberkulosis (TBC) berulang menjadi tantangan dalam target eliminasi TBC 2030 sehingga prioritas program, karena berpotensi resisten obat (RO). Tujuan penelitian ini untuk mengidentifikasi faktor risiko terjadinya kasus berulang. Penelitian dilaksanakan di Kabupaten Muara Enim Provinsi Sumatera Selatan selama 6 bulan menggunakan disain case-control study secara retrospektif. Sampel adalah...

The need of designing decentralized control loops emerges to ensure the global stability of a given process plant. To that purpose, the authors have proposed in recent works a systematic approach to derive robust decentralized controllers, which is based on the link between thermodynamics and passivity theory as well as on the fundamentals of process networks. This Thermodynamic-Based Control (...

The application of phase change materials (PCMs) has been verified as an effective strategy for improving energy efficiency and reducing greenhouse gas emissions. Biocomposite PCMs (Bc-PCM) exhibit large latent heat, chemical stability, a wide temperature range. In this study, thermal conductivity improved Bc-PCM (TBc-PCM) was made via vacuum impregnation with graphene nanoplatelets (GNPs). Che...

Nadat Robert Koch in 1882 stevige bewijzen geleverd had voor de associatie van Mycobacterium tuberculosis met gevreesde endemische tuberculose (tering, TBC) bij mensen, volgden al snel beschrijvingen analoge infecties allerhande diersoorten. Van meet af aan was het duidelijk dat vooral runderen endemisch geïnfecteerd waren pathogene mycobacteriën. stelde zijn eerste beschrijving zelfs verwekker...

BACKGROUND Prior traumatic experiences have been associated with poorer coping strategies, greater distress, and more posttraumatic stress disorder (PTSD) symptoms following a subsequent cancer diagnosis affecting their survival. However, the impact of prior physical traumatic injury on cancer survival has not been examined. METHODS The present study matched patients from the same Level 1 Tra...

Thermal barrier coating (TBC) systems are known to be extremely sensitive the applied thermo-mechanical loading in terms of both microstructure evolution and subsequent damage, leading final failure by ceramic top-coat layer spallation. The analysis relationship between mechanical behavior is limited scatter experimental results. Based on a typical TBC system for columnar top-coat, this study f...

BACKGROUND Few treatment options for alcohol use disorders (AUDs) exist and more are critically needed. Here, we assessed whether trace amine associated receptor 1 (TAAR1), a modulator of brain monoamine systems, is involved in the behavioral and reinforcement-related effects of ethanol and whether it could potentially serve as a therapeutic target. METHODS Wild-type (WT) and TAAR1 knockout (...

PURPOSE To evaluate the EX-PRESS P-50 implant compared to standard trabeculectomy (TBC). METHODS Single-center prospective randomized study; 20 eyes of 20 patients were treated with the EX-PRESS P-50 implant, and 20 eyes of 20 patients with TBC, over a 19-month period. Records of all patients were reviewed and compared. Success was defined as intraocular pressure (IOP) <21 and >5 mmHg or a de...

Neurons secrete neuropeptides from dense core vesicles (DCVs) to modulate neuronal activity. Little is known about how neurons manage to differentially regulate the release of synaptic vesicles (SVs) and DCVs. To analyze this, we screened all Caenorhabditis elegans Rab GTPases and Tre2/Bub2/Cdc16 (TBC) domain containing GTPase-activating proteins (GAPs) for defects in DCV release from C. elegan...