background: vitamin d deficiency may play a key role in the development of impaired glucose tolerance, type 2 diabetes mellitus (t2dm), and metabolic syndrome. several studies have shown that vitamin d has an antioxidant property. we aimed to investigate 25?hydroxy vitamin d (25[oh]d) levels in patients with t2dm and in nondiabetic healthy controls and to ascertain the impact of 25(oh)d levels ...

Diabetes is a serious global health problem. Large-scale genome-wide association studies identified loci for type 2 diabetes mellitus (T2DM), including adiponectin (ADIPOQ) gene and transcription factor 7-like 2 (TCF7L2), but few studies clarified the effect of genetic polymorphisms of ADIPOQ and TCF7L2 on risk of T2DM. We attempted to elucidate association between T2DM and polymorphic variatio...

The thiazolidinediones (TZDs) rosiglitazone (ROS) and pioglitazone (PIO) are insulin-sensitising agents widely used to treat patients with type 2 diabetes mellitus (T2DM). Thiazolidinediones significantly improve glycaemic control in diabetics by reduced fasting glucose, insulin and glycated haemoglobin and they delay the progression of insulin resistance/impaired glucose tolerance into T2DM. I...

Abstract Background The aim of the study was a retrospective comparison differences in maternal-foetal outcomes between women with type 1 and 2 diabetes mellitus (T1DM T2DM). Methods A cohort 135 patients pregestational diabetes, 73 T1DM (mean age 29 ± 5 years) 62 T2DM 33 6 years), intensive insulin treatment throughout pregnancy were evaluated. Clinical metabolic parameters prevalence maternal...

OBJECTIVE Air pollution is a novel risk factor for insulin resistance and occurrence of type 2 diabetes mellitus (T2DM), but the evidence is limited and diverse. Therefore, the aim of this study was to assess the effect of environmental air pollution on incidence of type 2 diabetes mellitus. METHODS In this study, we identified 102 published studies through a systematic data base search inclu...

The World is facing diabetic explosion and the cause may be both nature and nurture. According to the World Health Organization (WHO), diabetes mellitus affects approximately 171 million people worldwide and the number is expected to reach to 366 million in 2030 (Amos et al., 2010). Evidence is accumulating that the fundamental defect of type 2 diabetes mellitus (T2DM) is primarily associated w...

UNLABELLED Although macrovascular complications are typical for type 2 diabetes mellitus (T2DM), cerebral microvascular damage develops both in type 1 diabetes mellitus (T1DM) and T2DM. Color Doppler ultrasound is widely used for the examination of large- and medium-sized arteries, whereas SPECT and MRI are capable of identifying disturbances in the circulation of microvessels. Former studies u...

sodium-glucose co-transporter 2 (sglt2) inhibitors are a new glucose-lowering therapy for t2dm with documented benefits on blood glucose, hypertension, weight reduction and long term cardiovascular benefit. they have an inherent osmotic diuretic effect and lead to some volume loss and possible dehydration. there is some concern about the safety of using sglt2 inhibitors in muslim type 2 diabete...

Investigation of the clinical and pathogenesis aspects of osteoarthritis in combinations with diabetes mellitus type 2. Were studied 80 patients with osteoarthritis, 52 of them has a comorbidity disease such as diabetes mellitus type 2. Were investigated the clinical and radiological signs of disease severity, the levels of cytokines, NO, leptin, and CRP in serum, and levels of blood glucose, a...