Human islet amyloid polypeptide (IAPP or amylin) is a 37-residue hormone found as fibrillar deposits in pancreatic extracts of nearly all type II diabetics. Although the cellular toxicity of IAPP has been established, the structure of the fibrillar form found in these deposits is unknown. Here we have crystallized two segments from IAPP, which themselves form amyloid-like fibrils. The atomic st...

With the advancement of use geophysical methods in mining exploration, possibility restudying known mineral deposits that could have greater potential than previously estimated is opening up, as case Maricunga Belt (MB), which a metallogenic belt located east Copiapó, Chile, with length 200 km and oriented NNE-SSW direction. This hosts significant gold classified porphyry (-copper), epithermal ...

Levels of components of the classical and alternative complement pathways and the activity of the C3 nephritic factor (C3NeF) were measured in serum specimens from patients with type I (subendothelial deposits) and type II (intramembranous dense deposits) membranoproliferative glomerulonephritis (MPGN) and the results compared with the levels in normal subjects. Although C3 and C5 concentration...

Anti-glomerular basement membrane (anti-GBM) disease is characterized by crescentic glomerulonephritis with immunoglobulin G (IgG) autoantibodies to the non-collagenous (NC1) domain of α3(IV) collagen presenting along the GBM. The patient clinically manifests with rapidly progressive glomerulonephritis (RPGN) with pulmonary hemorrhage (Goodpasture...

We reviewed 166 adult patients on long-term haemodialysis, dividing them into three groups according to the presence and type of shoulder pain. The 24 patients in group A, with spontaneous pain related to a supine posture, had been under haemodialysis for significantly longer than the others, and had a much higher incidence of carpal tunnel syndrome. Open or arthroscopic resection of the coraco...

The Markley Formation of north-central Texas is composed predominantly of terrestrial rocks that span the Pennsylvanian-Permian boundary. Plant-fossil-bearing outcrops of the Markley are complex and preserve distinct environments that probably differed in position on the landscape and habitat conditions. In superpositional order, basal paleosols evidence well drained but wet conditions and supp...

AIM To demonstrate the role of cytopathology in examining tumours found at post mortem examination. METHODS Tumour deposits were found in 25 hospital necropsies. Cytological diagnosis made at the time of necropsy was compared with subsequent paraffin wax embedded histological sections. RESULTS In 19 out of 20 cases with no previous histological diagnosis, cytology at the time of necropsy pr...