Nowadays herbal medicines of skin-whitening cosmetics are popular with women. We attempted to find the whitening activity compounds present in many herbal medicines used for this purpose and discuss their mechanisms in melanin biosynthesis. The 70% acetone extracts of 10 kinds of herbs were investigated for their mushroom tyrosinase activity inhibition. Among these 10 extracts, Chinese galls sh...

We investigated the kinetics of 4N-acetyl-pentapeptides, Ac-P1, Ac-P2, Ac-P3, and Ac-P4, regarding inhibition of mushroom tyrosinase activity. The peptides sequences of Ac-P1, Ac-P2, Ac-P3, and Ac-P4 were Ac-RSRFK, Ac-KSRFR, Ac-KSSFR, and Ac-RSRFS, respectively. The 4N-acetyl-pentapeptides were able to reduce the oxidation of l-DOPA by tyrosinase in a dose-dependent manner. Of the 4N-acetyl-pen...

Traditionally, Lentinula edodes are used in many Asian countries for the treatment of various chronic diseases. In current study, ethyl acetate fraction fruit body was obtained by standard bioassay-guided fractionation procedure. This resulted isolation three bioactive compounds (compound 1 already reported, compound 2 and 3 first time reported from this mushroom) their structures were characte...

BACKGROUND The mode of action of Lycium chinense Miller root extract in skin care has never been explored. In the present study, Lycium chinense Miller root was extracted by the supercritical fluid CO2 extraction method. METHODS In the present study, the components of the root extract were analyzed by HPLC. The effects of the extract on tyrosinase activity and melanin content were determined ...

More than 200 generic drugs were screened to identify the inhibitory activity on melanogenesis in mouse B16 melanoma cells. Cinnarizine and trazodone were identified as melanogenesis inhibitors. The inhibitory effects of the two drugs on cell survival, melanogenesis, and tyrosinase activity were investigated. The results showed that both cinnarizine and trazodone inhibited melanogenesis in B16 ...

Introduction: Tyrosinase is considered an important target of melanin biosynthesis inhibitors. Curcuma longa L. has been used in the Javanese traditional whitening cosmetics. This work aimed to explore effect C. extracts on mushroom tyrosinase activity and cytotoxicity extract towards murine skin cancer B16F10 cells. Methods: rhizomes were cold-extracted using ethanol 70% yielded 15.3% w/w (ECL...

The methanol extracts of three Macaranga species (M. denticulata, M. pruinosa, and M. gigantea) were screened to evaluate their total phenolic contents and activities as cholinesterase inhibitors, nitric oxide (NO) production inhibitors, tyrosinase inhibitors, and antioxidants. The bark of M. denticulata showed the highest total phenolic content (2682 mg gallic acid equivalent (GAE)/100 g) and ...

melanin protects the skin from the harmful effects of sunlight, but unwanted hyperpigmentation can also produce significant psychological stress. Melanin is synthesized in the melanosomes in melanocytes, which produce melanin by a process that involves the transformation of tyrosine into 3,4dihydroxyphenylalanine (L-DOPA) by the enzyme tyrosinase and the subsequent transformation of L-DOPA into...

color and plays a significant role in protection the skin from UV light; while overproduction and accumulation of melanin result in various skin dermatological disorders including melasma, freckles, age spots, and sites of actinic damage or other hyperpigmentations. Thus, melanogenic inhibitors have become increasingly important ingredients in medication and cosmetics for the prevention of hype...