نتایج جستجو برای: tyrosine kinase inhibitors
تعداد نتایج: 417183 فیلتر نتایج به سال:
Summary The biology of non-small cell lung cancer (NSCLC) is driven by a complex mutational landscape, and the detection driver molecular alterations next-generation sequencing key for identification druggable alterations. Thus, broad profiling displays standard-of-care approach particularly in patients with advanced adenocarcinoma at time initial diagnosis, but also acquired resistance to tyro...
Sperm capacitation is required for fertilization. At the molecular level, this process is associated with fast activation of protein kinase A. Downstream of this event, capacitating conditions lead to an increase in tyrosine phosphorylation. The identity of the tyrosine kinase(s) mediating this process has not been conclusively demonstrated. Recent experiments using stallion and human sperm hav...
Abstract Vascular endothelial (VE)-cadherin in adherens junctions is an essential component of the vascular barrier, critical for tissue homeostasis and implicated diseases such as cancer retinopathies. Inhibitors Src cytoplasmic tyrosine kinase have been applied to suppress VE-cadherin phosphorylation prevent excessive leakage, edema high interstitial pressure. Here we show that Src-related Ye...
The human epidermal growth factor receptor 2 (HER2) is a member of the erbB class of tyrosine kinase receptors. These proteins are normally expressed at the surface of healthy cells and play critical roles in the signal transduction cascade in a myriad of biochemical pathways responsible for cell growth and differentiation. However, it is widely known that amplification and subsequent overexpre...
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