The problem of finding and disposing explosive objects in the water areas seas rivers that remain as a result hostilities on territory our country is urgent requires appropriate technical equipment. support (equipment) for performing underwater work, which service with Armed Forces Ukraine, outdated can pose threat to life health sapper divers during performance complex combat tasks regular bas...

Growth factor signalling regulates multiple cellular functions and its misregulation has been linked to the development and progression of cancer. Ack1 (activated Cdc42-associated kinase 1, also known as TNK2) is a non-receptor tyrosine kinase that has been implicated in trafficking and degradation of epidermal growth factor receptor (EGFR), yet its precise functions remain elusive. In this rep...

Cloud platforms allow administrators or management applications with privileged accounts to remotely perform operations for specific tasks, such as deleting virtual hosts. When are leaked and conduct dangerous operations, severe security problems will appear on cloud platforms. To solve these problems, researchers focus auditing users’ behaviors. However, it is difficult automatically audit fin...

Post-translational modification with ubiquitin is one of the most important mechanisms in the regulation of protein stability and function. However, the high reversibility of this modification is the main obstacle for the isolation and characterization of ubiquitylated proteins. To overcome this problem, we have developed tandem-repeated ubiquitin-binding entities (TUBEs) based on ubiquitin-ass...

After three years of discussion and early prototypes, the Federal Environment Agency (UBA), Germany, now has launched a two-year research & development project on Linked Environment Data (LED) with innoQ Deutschland GmbH as a contractor. This project will set up a core cloud of environment data with a well-elaborated domain terminology as its semantic backbone. Data will be taken from the “Envi...

Aggregated misfolded proteins are hallmarks of most neurodegenerative diseases. In a chronic disease state, including pathologic situations of oxidative stress, these proteins are sequestered into inclusions. Accumulation of aggregated proteins can be prevented by chaperones, or by targeting their degradation to the UPS. If the accumulation of these proteins exceeds their degradation, they may ...

JUAN F. SAAD1, M. ROMINA SCHIAFFINO1, ALICIAVINOCUR1,2, INÉS O’FARRELL1, GUILLERMO TELL1 AND IRINA IZAGUIRRE1* 1 DEPARTAMENTO DE ECOLOGÍA, GENÉTICA Y EVOLUCIÓN, FACULTAD DE CIENCIAS EXACTAS Y NATURALES, UNIVERSIDAD DE BUENOS AIRES, IEGEBA (CONICET-UBA), BUENOS AIRES C1428EHA, ARGENTINA AND DEPARTAMENTO DE BIODIVERSIDAD Y BIOLOGÍA EXPERIMENTAL, FACULTAD DE CIENCIAS EXACTAS Y NATURALES, UNIVERSID...

The covalent modification of proteins by ubiquitination is a major regulatory mechanism of protein degradation and quality control, endocytosis, vesicular trafficking, cell-cycle control, stress response, DNA repair, growth-factor signalling, transcription, gene silencing and other areas of biology. A class of specific ubiquitin-binding domains mediates most of the effects of protein ubiquitina...

The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling. We report the solution structure of this C-terminal domain, which is based on a di...