Background TARDOX is a Phase I single center study of ultrasound triggered targeted drug delivery in adult oncology patients with incurable liver tumours. This proof of concept study is designed to demonstrate the safety and feasibility of targeted drug release and enhanced delivery of doxorubicin from thermally sensitive liposomes (ThermoDox®) triggered by mild hyperthermia induced by focused ...

Diagnostic ultrasound has an excellent safety record in general and, in particular, in obstetrics. As a form of energy, ultrasound has effects in insonated tissues that are caused by two main mechanisms: thermal and nonthermal (also known as mechanical). Onscreen indicators of these potential bioeffects are the thermal and mechanical indices. Biological effects of ultrasound have been reported ...

PURPOSE To evaluate the safety and initial efficacy of magnetic resonance (MR) imaging-guided focused ultrasound for the palliation of pain caused by bone metastases in patients in whom standard available treatments had been ineffective or not feasible. MATERIALS AND METHODS Informed consent was obtained in 11 patients (seven women, four men; average age, 58.6 years) with pain related to non-...

OBJECTIVE Ultrasound-guided regional anesthesia is recommended for nerve block due to its safety and reliability. Needle visualization is important when inserting needles into tissues in close proximity to target nerves. For safety reasons, the tip of the standard-type needle for application of nerve block is thinner than that of an interventional needle for insertion into intra-abdominal organ...

TOPIC: Procedures TYPE: Original Investigations PURPOSE: Ultrasound-guided core needle biopsy for peripheral thoracic lesions is increasingly being performed by trained pulmonologists with excellent diagnostic yields and safety. However, the performance of fully versus semi-automated has not been adequately assessed in literature. We aimed to compare yield safety these needles our pulmonologist...

Acoustic Cluster Therapy (ACT) represents a novel concept for targeted drug delivery. Ultrasound is applied to activate intravenously administered free-flowing clusters of microbubbles and microdroplets within the target pathology, depositing 20-30 μm large bubbles in the microvasculature for 5-10 min. Further application of ultrasound induces biomechanical effects which increase vascular perme...

The role of point-of-care ultrasound in mass casualty incidents (MCIs) is still evolving. Occasionally, hospitals can be destroyed by disasters resulting in large number of trauma patients. CAVEAT and FASTER ultrasound protocols, which are used in MCIs, included extremity ultrasound examination as part of them. The literature supports the use of ultrasound in diagnosing extremity fractures both...