We propose a system for the interpretation of anaphoric relationships between unbound pronouns and quantifiers. The main technical contribution of our proposal consists in combining generalized quantifiers with dependent types. Empirically, our system allows a uniform treatment of all types of unbound anaphora, including the notoriously difficult cases such as quantificational subordination, cu...

Timber supply has traditionally been modelled using aggregate data. In this paper, we build aggregate supply models for four roundwood products for the US state of North Carolina from a stand-level harvest choice model applied to detailed forest inventory. The simulated elasticities of pulpwood supply are much lower than reported by previous studies. Cross price elasticities indicate a dominant...

The objective of this study was to examine the interrelationships between maternal and fetal plasma drug protein binding, umbilical blood flow (Q(um)), gestational age (GA), and maternal-fetal diphenhydramine (DPHM) clearances in chronically instrumented pregnant sheep. Maternal and fetal DPHM placental (CL(mf) and CL(fm), respectively) and nonplacental (CL(mo) and CL(fo), respectively) clearan...

The IC50 values of 14 drugs were determined in recombinantly expressed CYP2C9 (rCYP2C9) and human hepatocytes and the data used to simulate clinical area under the plasma concentration-time curve (AUC) changes upon coadministration with prototypic CYP2C9 substrates. There was an excellent correlation between IC(50, apparent) values determined using diclofenac and naproxen as CYP2C9 substrates (...

Recent scientific concerns to achieve sustainability in construction have suggested the implementation of using recycled aggregate in concrete because it has the potential to reduce the demand for extraction of natural raw materials and decrease the volume of wastes landfilled. In this respect, this study aims to investigate the suitability of using ceramic tile (CT) and ceramic sanitary (CS) w...

The binding of the antibiotic kirromycin (mocimycin) to its target protein, bacterial elongation factor Tu (EF-Tu), has been studied by 1H NMR spectroscopy using deuterated protein. Narrow lines were observed in the spectrum of the unbound protein (due to residual protons) and in the spectrum of the kirromycin-EF-Tu complex. The spectrum of the complex has been compared with the spectra of the ...

The present paper offers a meso-scale numerical model to investigate the effects of random distribution of aggregate particles and steel fibers on the elastic modulus of Steel Fiber Reinforced Concrete (SFRC). Meso-scale model distinctively models coarse aggregate, cementitious mortar, and Interfacial Transition Zone (ITZ) between aggregate, mortar, and steel fibers with their respective materi...

Previous studies have demonstrated high, concentration-dependent serum protein binding of cefonicid. To determine the in vivo pharmacokinetic significance of these observations, the pharmacokinetics of both total and unbound (non-protein-bound) cefonicid was studied in six volunteers after a single intravenous dose of 30 mg/kg. Saturable serum protein binding was observed in vivo; the mean +/- ...