Because of the potential of novobiocin-rifampin for oral therapy of methicillin-resistant Staphylococcus aureus infection, we evaluated the pharmacokinetics of novobiocin and rifampin, alone and in combination, in a randomized, crossover, multiple-dose evaluation (500 mg of novobiocin and 300 mg of rifampin administered orally, twice a day, for 27 doses) in 10 volunteers. The half-lives of novo...

Results M orphine injection delayed clopidogrel absorption (p 1⁄4 0.025) and reduced the area under the curve levels of its active metabolite by 34% (p 1⁄4 0.001). Morphine delayed the maximal inhibition of platelet aggregation on average by 2 h (n 1⁄4 24; p < 0.001). Residual platelet aggregation was higher 1 to 4 h after morphine injection (n 1⁄4 24; p < 0.005). Furthermore, morphine delayed ...

in july 2003, the bellagio study group on child survival estimated that the lives of 6 million children could be saved each year if 23 proven interventions were universally available in the 42 countries re-sponsible for 90% of child deaths in 2000. the aim of this study was to determine frequency of important causes of mortality among under-5 year old children in hospitals, tehran, iran. inform...

background: informal payments in the health sector of many developing countries are considered as a major impediment to health care reforms. informal payments are a form of systemic fraud and have adverse effects on the performance of the health system. in this study, the frequency and extent of informal payments as well as the determinants of these payments were investigated in general hospita...

with the beginning of the 19th century, england entered into a transitional period. sociologists believe that in each era of transformation, the ruling class tries to establish its own values, but some resistance to these new values is inevitable. thomas hardy's novels in general, and under the greenwood tree specifically, are no exception. based on these notions, this paper tries to interpret ...

INTRODUCTION There are no existing data on whether performance on the United States Medical Licensing Examination (USMLE) predicts success in American Board of Emergency Medicine (ABEM) certification. The aim of this study was to determine the presence of any association between USMLE scores and first-time success on the ABEM qualifying and oral certification examinations. METHODS We retrospe...

Institute of Artificial Photosynthesis, State Key Laboratory of Fine Chemicals, DUT–KTH Joint Education and Research Centre on Molecular Devices, Dalian University of Technology (DUT), 2 Linggong Road, 116024 Dalian, China School of Chemical Science and Engineering, Centre of Molecular Devices, Department of Chemistry, KTH Royal Institute of Technology, Teknikringen 30, 10044 Stockholm, Sweden ...

Few data exist on the temporal relationship between catecholamines and muscle force production in vivo. The purpose of this study was to examine the influence of preexercise arousal on sympathoadrenal neurohormones on muscular force expression during resistance exercise. Ten resistance-trained men completed two experimental conditions separated by 7 days: 1) acute heavy resistance exercise prot...

OBJECTIVE This study investigated whether baseline cortisol measures predicted future anxiety, and compared cortisol values of groups with different developmental pathways of anxiety. METHOD Cortisol levels were assessed in 1768 individuals (10-12 years). Anxiety levels were assessed at the same age and 2 years later. RESULTS Cortisol measures did not predict future anxiety levels. Individu...

Using case studies and concepts we suggest that constraints upon aggregate or global forest transition are significantly more severe than those upon local forest reversals. The basic reason is that one region’s reversal can be facilitated by other regions that supply resources and goods, reducing the demands upon the region where forests rise. Many past forest reversals involve such interdepend...