The collected comments and pathologic diagnoses of several pathologists are summarized for 18 cases in which lesions were induced in the upper respiratory tract of rats and mice. Specific neoplastic and nonneoplastic lesions of the nose and trachea are described and discussed, and opinions regarding pathogenesis and biologic significance of the lesions are presented. The anatomic and pathophysi...

Early life infections with human bocavirus 1 (HBoV-1) are common, and the virus is readily detected in the upper respiratory tract, often during acute upper respiratory tract illness. Its etiological role in respiratory tract infections has been uncertain because of its presence in asymptomatic children and frequent concurrent detection of other respiratory viruses. Longitudinal cohort studies,...

Many competitive sportsmen in this country regularly use pollen extract as a dietary supplement in the belief that it can lead to an improvement in performance. We have investigated the effects of a six-week course of pollen extract administration on a variety of physiological parameters in a group (n = 20) of adolescent swimmers. At the time of the study, all subjects were training on a daily ...

From 2008-2011 to 2012-2015, the percentage of visits for acute viral upper respiratory tract infection that had an antimicrobial ordered or prescribed decreased from 37.1% to 25.5% among emergency departments (EDs) located in nonmetropolitan statistical areas, but this decline was not seen among EDs in metropolitan statistical areas. In 2008-2011, the percentage was higher among nonmetropolita...

BACKGROUND Little is known about the magnitude of deficits in the quality of care delivered to children, since comprehensive studies have been lacking. METHODS We assessed the extent to which care processes recommended for pediatric outpatients are delivered. Quality indicators were developed with the use of the RAND-UCLA modified Delphi method. Parents of 1536 children who were randomly sele...

OBJECTIVE Urgent care centres' (UCCs) hours were developed with the aim of reducing inappropriate emergency department (ED) attendances in England. We aimed to examine the presenting complaint and outcomes of care in 2 general practitioner (GP)-led UCCs with extended opening times. DESIGN Retrospective observational epidemiological study using routinely collected data. SETTING 2 GP-led UCCs...

Among 214 patients consulting their general practitioner with upper respiratory tract infection, differences in expectation were apparent between Whites, Afro-Caribbeans and Asians. Significantly more Asians (84%) wanted prescriptions for antibiotics and/or other medication than did Afro-Caribbeans (72%) or Whites (47%) (P<O.001). There were no significant differences in terms of what was recei...

The normal lung has several defence mechanisms to deal with microorganisms. Lower respiratory infections in the absence of lung disease are therefore relatively infrequent as compared with upper respiratory tract infections in healthy adults. In the setting of chronic obstructive pulmonary disease (COPD), lower respiratory tract infections, both acute and chronic, occur with increased frequency...

The lining of the nose and paranasal sinuses is continuous and it would be rare for inflammation to affect one without the other. In addition, the symptoms of sinusitis, particularly chronic sinusitis, and rhinitis overlap to a large extent and it is therefore convenient to consider the two together as rhinosinusitis. Similarly, the upper respiratory tract (nose and paranasal passages) and lowe...

Patients with ANCA-associated vasculitides usually present similar clinical manifestations (fever, joint pain, lung and kidney diseases, purpura, etc.). However, signs of granulomatosis inflammation the upper lower respiratory tract and/or orbit allow to differentiate polyangiitis (GPA) from microscopic (MPA). Circulating ANCAs are key laboratory sign vasculitis, although they can be negative i...