The Jerne plaquing technique for the demonstration of single antibody-forming cells was employed to study the kinetics of the antibody response that accompanies experimental immunogenic uveitis in rabbits produced by intravitreal injection of sheep erythrocyte stromas. Prior to the onset of uveitis, a modest increase in antibody formation in the spleen can be detected. With the appearance of uv...

We retrospectively reviewed ultrasonographic data on 32 uveal melanomas that had been studied both at a referral institution and at our centre within a six-week period. Generally there were good correlations between ultrasonographic measurements of tumour thickness. The mean absolute difference in ultrasound measurements of tumour thickness was 0.64 mm (range 0-2.2 mm); the mean tumour thicknes...

Dear Editor: We read with interest the article “Approach of Turkish ophthalmologists to micronutrition in age-related macular degeneration” by Şahın et al. They aimed to evaluate the knowledge and behavior of ophthalmologists in Turkey with regard to micronutrition support in patients with age-related macular degeneration (ARMD). We congratulate the authors on their well-designed study. We woul...

A case is presented to illustrate the difficulties encountered in the clinical diagnosis ofan intraocular mass. The fundus was not visible ophthalmoscopically because of opaque media. The anterior surface of the iris showed three discrete hyperpigmented nodular patches. Ultrasound showed an intraocular mass occupying half the posterior segment. The eye did not have useful vision and was enuclea...

SCBH was induced by immunizing guinea pigs with a protein antigen and challenging 1 week later with a large intraperitoneal dose of the same antigen. Animals developed a delayed-onset, erythematous skin rash and dermal infiltration by basophils and eosinophils. The uveal tracts of these animals were infiltrated by eosinophils, as were several other internal organs. The eye is affected in SCBH, ...

Since Ernst Fuchs's publication on sarcoma of the uveal tract,' in which he stated that malignant melanoma does not metastasise to the eye, more than 40 cases have been reported.2-28 An autopsy series of 15 patients who had died from disseminated cutaneous malignant melanoma, and who had no ocular symptoms, showed a 33% incidence of ocular metastases.29 The case is reported here of a man who, b...

OBJECTIVES SOX-10 has been shown to be a sensitive marker of cutaneous melanoma. This study aimed to evaluate Sox-10 expression in uveal melanoma. METHODS A total of 40 tissue blocks of enucleated eyes with uveal melanoma were cut and stained using an anti-SOX-10 mouse monoclonal antibody and HMB-45 antibody. RESULTS SOX-10 showed exclusive nuclear positivity in 100% of the uveal melanoma c...