The pneumococcus is a major otitis media (OM) pathogen, but data are conflicting regarding whether otitis-prone children have impaired humoral immunity to pneumococcal antigens. We and others have shown that otitis-prone and healthy children have similar antibody titers to pneumococcal proteins and polysaccharides (vaccine and nonvaccine types); however, the quality of antibodies from otitis-pr...

This study was conducted to optimize a fusion protein vaccine for translational development as against the human tropical parasitic infection, lymphatic filariasis (LF). The candidate, His-tagged r Bm HAXT developed previously in our laboratory and tested various animal models including mouse, gerbils Rhesus macaque where it exhibited significant levels of vaccine-induced protection. However, c...

Nucleic acid vaccines represent an attractive approach to generating antigen-specific immunity because of their stability and simplicity of delivery. However, there is still a need to increase the potency of DNA vaccines. Using human papillomavirus type 16 E7 as a model antigen, we evaluated the effect of linkage to Mycobacterium tuberculosis heat shock protein 70 (HSP70) on the potency of anti...

rb51 new vaccine with notable characteristics such as doesn’t induce disturbing antibodies in routine diagnostic tests, has used since 2002 in iran. with special attention to this subject and lack of valid epidemiological studies for field evaluation of rb51, this ecological investigation was conducted during 1996 to 2006 in tehran province farms. data were obtained from veterinary organization...

Development of an effective HIV/AIDS vaccine remains a big challenge, largely due to the enormous HIV diversity which propels immune escape. Thus novel vaccine strategies are targeting multiple variants of conserved antibody and T cell epitopic regions which would incur a huge fitness cost to the virus in the event of mutational escape. Besides immunogen design, the delivery modality is critica...