PURPOSE to correlate the presence of yeast from the Candida genus in the oral and vaginal cavity of women with and without vulvovaginal candidiasis (VVC), with secretor IgA levels (IgAs) present in the saliva. METHODS among the 51 women included, 13 presented VVC and 38 were the Control Group. An amount of 2.0 mL of saliva without stimulation was collected from each patient, plus vaginal secr...

Secreted aspartyl proteinases (Saps) contribute to the ability of Candida albicans to cause mucosal and disseminated infections. A model of vaginal candidiasis based on reconstituted human vaginal epithelium (RHVE) was used to study the expression and role of these C. albicans proteinases during infection and tissue damage of vaginal epithelium. Colonization of the RHVE by C. albicans SC5314 di...

Vulvovaginal candidiasis (VVC) is an opportunistic mucosal infection caused by Candida albicans that affects large numbers of otherwise healthy women of childbearing age. Acute episodes of VVC often occur during pregnancy and during the luteal phase of the menstrual cycle, when levels of progesterone and estrogen are elevated. Although estrogen-dependent experimental rodent models of C. albican...

BACKGROUND Recurrent vulvovaginal candidiasis (VVC) remains a challenge to manage in clinical practice. Recent epidemiologic studies indicate that non-albicans Candida spp. are more resistant to conventional antifungal treatment with azoles and are considered as causative pathogens of vulvovaginal candidiasis. METHODS We searched PubMed and Scopus for studies that reported clinical evidence o...

OBJECTIVE To evaluate the role of Mycoplasma hominis as a vaginal pathogen. DESIGN Prospective study comprising detailed history, clinical examination, sexually transmitted infection (STI) and bacterial vaginosis screen, vaginal swabs for mycoplasmas and other organisms, follow up of bacterial vaginosis patients, and analysis of results using SPSS package. SETTING Genitourinary medicine cli...

OBJECTIVE Although recurrent vulvovaginal candidiasis is defined as 4 or more discrete attacks of vulvovaginal candidiasis per year, there is no diagnostic nomenclature or definition for the many women who are chronically symptomatic. This study aims to establish and propose a definition and a set of diagnostic criteria, which would enable clinicians to promptly identify and treat women with ch...

The commensal fungus Candida albicans causes oropharyngeal candidiasis (OPC; thrush) in settings of immunodeficiency. Although disseminated, vaginal, and oral candidiasis are all caused by C. albicans species, host defense against C. albicans varies by anatomical location. T helper 1 (Th1) cells have long been implicated in defense against candidiasis, whereas the role of Th17 cells remains con...

Vulvovaginal Candidiasis (VVC) is a fungal infection caused by Candida spp. of the genital mucosa that still health concern for women.This first-of-its-kind investigation on isolation dubliniensis, from cervical-vulvovaginal patients in Erbil hospitals. The study was carried out and identification which performed using phenotypic molecular approaches. A total one hundred samples vaginal swabs (...

Background The Ocotea minarum is a plant native to Cerrado and found in abundance in this Brazilian biome. Belonging to the family Lauraceae is popularly known in the region as “Shin-broom”. It is a medium-sized tree, occurring in several states, among them, the Mato Grosso do Sul. Due to the presence of some compounds such as tannins, steroids, triterpenes and flavonoids in its shell, it may h...

Deletion of both alleles of the Candida albicans CaHK1 gene, which causes cells to flocculate when grown at pH 7.5, a pH comparable to that of mammalian blood, abolishes the ability of the yeast to establish a successful infection in a murine model of hematogenously disseminated candidiasis. Within 72 h all mice inoculated with the parental C. albicans strain had died. The mice infected with ei...