BACKGROUND To evaluate and compare the efficacy of vaginal misoprostol and a rectal nonsteroidal anti-inflammatory drug (NSAID) on pain relief during Pipelle endometrial biopsies in a placebo-controlled randomized study. METHODS One hundred and fifty-one women who had an indication for a Pipelle endometrial biopsy were randomized into three groups as follows: group 1, vaginal misoprostol; gro...

Despite extensive knowledge of the mechanisms responsible for childbirth, course labor induction is often unpredictable. Therefore, protocols using prostaglandin analogs have been developed and tested to assess their effectiveness in unequivocally. A total 402 women were collected into two groups—receiving vaginal Misoprostol or Dinoprostone (IOL). Then, patients compared groups depending on ag...

Objective: Retrospective analysis and evaluating reliability and efficiency of misoprostol in 87 cases having pregnancy termination by using vaginal misoprostol between 12 and 35 weeks’ gestation. Methods: The present study was conducted at Celal Bayar University, Gynecology and Obstetrics Clinic, Perinatology unit between January 2006 and November 2008. A total of 87 cases at more than 12 week...

Objective  To survey obstetrical provider preferences regarding use of misoprostol for induction of labor (IOL). Methods  An anonymous 25-question survey was distributed at an American College of Obstetricians and Gynecologists (ACOG) joint District V and VII Meeting in 2014 to obstetrics providers. The same survey was sent electronically to local providers. A separate survey was emailed to the...

OBJECTIVE To test the effectiveness and safety of low-dose vaginal misoprostol for induction of labor with a live fetus. METHODS Labor was induced in 666 pregnant women with a live fetus in the cephalic position, who had no medical complications and no history of uterine surgery. One-fourth of a 200-micrograms tablet of misoprostol (50 micrograms) was placed in the posterior vaginal fornix ev...

BACKGROUND A postpartum hemorrhage prevention program to increase uterotonic coverage for home and facility births was introduced in two districts of Liberia. Advance distribution of misoprostol was offered during antenatal care (ANC) and home visits. Feasibility, acceptability, effectiveness of distribution mechanisms and uterotonic coverage were evaluated. METHODS Eight facilities were stre...

OBJECTIVE To evaluate whether routine administration of sublingual misoprostol 600 microg after delivery reduces postpartum haemorrhage. DESIGN Randomised double blind placebo controlled trial. SETTING Primary health centre in Bissau, Guinea-Bissau, West Africa. PARTICIPANTS 661 women undergoing vaginal delivery. INTERVENTION Misoprostol 600 mug or placebo administered sublingually imme...

BACKGROUND Dilatation and curettage (D&C) has been the usual treatment for early pregnancy failure (EPF). Medical management with misoprostol may be an effective alternative. Bleeding patterns during and after medical management of EPF are unknown. METHODS A prospective cohort study was conducted at University-based clinics and physician offices. Eighty women <11 weeks estimated gestational a...

BACKGROUND Postpartum haemorrhage (PPH) is the third-most common cause of maternal death in the United States and it is still the first prevalent cause of maternal death in developing countries. Active prevention of haemorrhage with an uterotonic or other new drugs leads to a decrease in postpartum vaginal haemorrhage. The aim of this study was to compare anti-haemorrhagic effect of Tranexamic ...