Chagas disease is an endemic parasitic infection that occurs in 21 Latin American countries. New therapies for this disease are urgently needed, as the only two drugs available (nifurtimox and benznidazol) have high toxicity and variable efficacy in the disease's chronic phase. Recently, a new chemical entity (NCE) named Pyranaphthoquinone (IVS320) was synthesized from lawsone. We report herein...

in this research, the bioinsising impact of two wood decay fungi (pysisporinus vitreus and xylaria longipes) on radial air permeability and moisture diffusion coefficient of spruce wood (picea abies) was investigated. fungal cultivation was performed in an incubator at 25 °c and 85% relative humidity for 15, 30 and 45 days. results showed that the permeability, moisture diffusion and mass loss ...

The myocardial transmicrovascular transport of thallium-201 (201Tl) and technetium-99m hexakis(2-methoxyisobutylisonitrile) (MIBI) were compared during variable blood flow levels in nine blood-perfused, isolated rabbit hearts. Seventeen injections of radiolabeled albumin and EDTA as well as 201Tl and MIBI were performed by indicator-dilution techniques. When coronary flow was varied from 0.52 t...

Red blood cells from patients with sickle cell disease (SCD) exhibit increased electrogenic cation permeability, particularly following deoxygenation and hemoglobin (Hb) polymerisation. This cation permeability, termed Psickle, contributes to cellular dehydration and sickling, and its inhibition remains a major goal for SCD treatment. Nevertheless, its characteristics remain poorly defined, its...

Permeable pavements are a common solution for wearing course layers in roads and urban areas. They composed by highly porous materials with permeability several orders of magnitude above the natural terrain. This work presents, on one hand, experimental characterisation hydraulic behaviour permeable asphalt concrete layer and, other development validation two-dimensional coupled hydraulic-hydro...

The connectivity and tortuosity of fluid-filled pore networks in the water air phases strongly influence mass transport porous media. Moisture conditions (water content distribution) alter water- or air-filled networks. In this study, using a sand column with variable saturated conditions, were analyzed X-ray computed tomography (CT). Water parameters, including hydraulic conductivity, gas diff...

estrogen replacement therapy (ert) in postmenopausal women may decrease the risk of coronary artery diseases (cad). we hypothesized that nitric oxide (no) releasing due to ert may be the essential factor by which endothelial permeability decreases. four groups of ovariectomized rabbits were under investigation for five weeks. groups 1 & 4 received high cholesterol diet and other two groups (2 &...

Soil-atmosphere interaction has been attracting increasing interest as the seasonal variation of pore water pressures (pwp) linked to a variety geotechnical problems (e.g. slope stability and serviceability, foundation subsidence or swelling, desiccation cracking etc.) identified part solution in sustainable urban drainage systems). Prediction how pwp will change within soils low permeability u...