We present the first case of retrograde ablation of the small saphenous vein to treat active venous ulceration. A 73-year-old gentleman with complicated varicose veins of the left leg and a non-healing venous ulcer despite previous successful endovenous treatment to his left great saphenous vein underwent mechanochemical ablation of his small saphenous vein with the ClariVein® system, under loc...

Varicose vein (VV) surgery remains one of the commonest surgical operations performed across Europe. In the UK, it is also the commonest single cause of medico-legal action against general and vascular surgeons. Most of these actions appear to arise because patients have a poor understanding of the risks and benefits of intervention and are, therefore, surprised and aggrieved when the end-resul...

Chronic venous disease (CVeD) is a prevalent condition with a significant socioeconomic burden, yet the pathophysiology is only just beginning to be understood. Previous studies concerning the dysregulation of matrix metalloproteinases (MMPs) and their inhibitors (tissue inhibitors of metalloproteinases (TIMPs)) within the varicose vein wall are inconsistent and disregard clinical progression. ...