Enzyme linked immunosorbent assays with an ultrasonicate of Treponema pallidum (TP-ELISA) or axial filament of Treponema phagedenis biotype Reiter (AF-ELISA) were developed to detect treponemal antibody. TP-ELISA and AF-ELISA were compared with the T pallidum haemagglutination assay (TPHA), the fluorescent treponemal antibody-absorbed (FTA-ABS) test, and the Venereal Disease Research Laboratory...

A group of seven young women with antiphospholipid antibodies, histories of recurrent fetal loss, and no live births is reported. Two patients had systemic lupus erythematosus, and the other five fulfilled criteria for the primary antiphospholipid syndrome. A false Venereal Disease Research Laboratory (VDRL) test was present in four of the patients, three had a previous episode of arterial or v...

At present, diagnosis for neurosyphilis remains a major clinical challenge. Venereal Disease Research Laboratory (VDRL) titer of the cerebrospinal fluid (CSF) is suboptimally sensitive to diagnose neurosyphilis, which can be negative in neurosyphilis patients, especially in asymptomatic neurosyphilis patients. In the search for biomarkers of neurosyphilis, we investigated the chemokine profile ...

Here we report the occurrence of pale yellowish perivascular preretinal dots in 12 patients with ocular syphilis. A case series of these patients was examined between March and October 2012 at the Uveitis Sector of Universidade Federal de São Paulo. After diagnostic confirmation of syphilis, fundus photographs and optical coherence tomography (OCT) were performed to verify the localization of t...

Neurosyphilis follows a more aggressive and different clinical course in HIV-infected patients compared to patients with normal immunity. Two historical series of patients with a diagnosis of neurosyphilis between 1995 and 2008 were compared: they included a group of 15 patients with y and 28 patients without HIV infection. Probability of neurosyphilis in patients with positive serum VDRL was i...

Latar Belakang: Dalam Profil Kesehatan Provinsi Jawa Barat, AKI pada tahun 2016 mencapai 799 ibu meninggal dan AKB di Barat sebesar 3.702 bayi meninggal. Bersamaan dengan itu kesehatan memiliki resiko penularan dari ke anak untuk HIV adalah 20%-45%, Sifilis 69-80%, Hepatitis B lebih 90%. Tujuan: Penelitian ini bertujuan mengetahui hubungan antara sumber informasi, peran bidan riwayat kehamilan ...

BACKGROUND Treponema pallidum infection evokes vigorous immune responses, resulting in tissue damage. Several studies have demonstrated that IL-17 may be involved in the pathogenesis of syphilis. However, the role of Th17 response in neurosyphilis remains unclear. METHODOLOGY/PRINCIPAL FINDINGS In this study, Th17 in peripheral blood from 103 neurosyphilis patients, 69 syphilis patients witho...

OBJECTIVE To define clinical and laboratory features that identify patients with neurosyphilis. METHODS Subjects (n=326) with syphilis but no previous neurosyphilis who met 1993 Centers for Disease Control and Prevention criteria for lumbar puncture underwent standardized history, neurological examination, venipuncture, and lumbar puncture. Neurosyphilis was defined as a cerebrospinal fluid (...

Syphilis is a sexually transmitted disease caused by a spirochete, Treponema pallidum (T. pallidum). Involvement of the central nervous system (CNS) occurs in 5-30% of the patients and the CNS may be affected at any stage of the disease (1). It is difficult to differentiate neurosyphilis from other cerebral infectious and inflammatory diseases, because of its various times of onset and diverse ...