Congenital heart disease (CHD) is a complex illness with high rates of morbidity and mortality. In embryonic development, the heart is the first formed organ, which is strictly controlled by gene regulatory networks, including transcription factors, signaling pathways, epigenetic factors and microRNAs. Bone morphogenetic protein (BMP)-2 and -4 are essential in cardiogenesis as they can induce t...

Biofouling of medical devices involves the formation of a biofilm by bacteria. The infecting bacteria produce extensive exopolysaccharides to form a confluent biofilm. Bacteria within a biofilm can be 1,000 times more resistant to antimicrobials than their planktonic counterparts and less susceptible to host immune systems. According to an estimate by the NIH (USA), about 80% of all human bacte...

onsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed but can have serious gastro inal (GI) and cardiovascular side effects, which have led to the withdrawal of some of these d ontinuing uncertainty about the best approach to patients requiring NSAID therapy, particularly i ith GI or cardiovascular risk factors. To define the risks to the GI and cardiovascular systems a ith NSAID t...

We use multiple longitudinal data sources and propensity score matching to assess the long-term outcomes of the Neighborhood Transformation Initiative (NTI) in the Sandtown-Winchester community of Baltimore. This comprehensive community initiative, implemented in the 1990s, remains one of the most well-known urban revitalization projects in the country, due to its significant funding (more than...

Today’s business environment pushes organizations to be adaptive and collaborative. This push drives the development of service-oriented enterprise architecture (SOEA) in support of the organization. To realise the advantages offered by SOEA, research on avoiding SOEA implementation failure is of considerable merit. In the review of literature on SOEA implementation failure, two research proble...

This paper describes a novel mechanism that supports a global atomicity primitive. In distributed systems, it is important that concurrent access to shared data items does not violate some pre-de ned notion of consistency. A global atomicity primitive is a simple programming paradigm for controlling access to shared data, that guarantees to preserve consistency (provided individual processes do...

We studied a new commercially available thyrotropin (TSH) assay, the AquaLite Bioluminescence TSH-Immunoassay (SeaLite Inc.). This assay has a detection limit of 0.005 mIU/L and a functional sensitivity of 0.017 mIU/L and meets the requirements of a third-generation TSH assay. Using this assay, we measured serum TSH in 153 euthyroid individuals and in the following patients: 32 primary hypothyr...

The main ideas of Kant’s moral philosophy were embodied in what can be called the “Enlightenment Project”. calls for freedom, nti-paternalism and requirement abandonment concern behaviour are associated with ethical autonomy, categorical imperative, negative positive universality morality relation to human being as a rational actor etc. These consistent ideals following distinguished: 1) ideal ...

Multiple transmit and receive antennas are a means to increase wireless capacity [1, 2]. Recently, there has been considerable research in exploiting the space dimension through transmit diversity, and spatial multiplexing which is used to transmit multiple data streams that can be separated using receiver signal processing, e.g., [3–5]. Spatial multiplexing can significantly benefit from trans...