Five racehorses in apparently normal condition succumbed to sudden cardiac death (SCD) during or shortly after intensive training exercise. Cardiopathologic examination was performed. In 1 of the 5 horses, the use of an electrocardiogram (ECG) recording taken continuously for 440 sec enabled us to analyze some of the arrhythmias in the terminal event of SCD. The ECG tracing exhibited the R-on-T...

Atrial, His bundle (H), and ventricular electrograms were recorded by an electrode catheter in unanesthetized man. Conduction time through the atrioventricular (A-V) conduction system was subdivided into A-V nodal (A-H interval) and ventricular specialized conduction system (H-V interval). The right atrium was driven at a constant rate and the pattern of A-V conduction of premature atrial test ...

The developmental appearance and spatial distribution pattern of gap junctions were studied in prenatal and adult rat hearts. Gap junctions were visualized immunohistochemically with an antibody raised against a unique cytoplasmic epitope of connexin43, and the spatial distribution pattern was determined by three-dimensional reconstruction. The results demonstrate that from embryonic day 13 onw...

A novel type of cardiac myosin heavy chain, immunologically related to the myosin isoforms expressed during skeletal muscle development, has recently been described in sinoatrial and atrioventricular nodal fibers of the adult bovine heart (Gorza et al, J Cell Biol 1986; 102:1758-1766). The tissue-specific expression of this myosin type has been utilized in the present study to investigate the d...

Previous studies have demonstrated that the extracellular space (ECS) component of the atrioventricular (AV) node and His bundle region is larger than the ECS in adjacent contractile myocardium. The potential physiological significance of this observation was examined in a canine blood-perfused AV nodal preparation. Mannitol, an ECS osmotic expander, was infused directly into either the AV node...

tive examination. Internal morphology of the left appendage revealed a smooth endocardium without a crista terminalis and was of the left atria1 type. The presence of left atria1 isomerism associated with a common atrium led to the diagnosis of ambiguous AV connection. Surgical correction involved rerouting the systemic venous return to the tricuspid valve. This was achieved with a “mirror imag...

Appropriate heart rate in a failing pulmonary ventricle remains unknown, particularly congenital disease with unique hemodynamics. A 71-year-old male repaired tetralogy of Fallot and pacemaker for sinus node dysfunction suffered from failure symptoms preserved left ventricular function. Simply changing the pacemaker’s lower 60 to 75 bpm, New York Heart Association classification improved III II...

In four patients with WPW syndrome atrial and ventricular premature beats were induced and the changes in form of the ventricular and atrial complexes were studied. Results indicate that, depending upon the timing of the premature atrial beat and the state of refractoriness of the His and Kent bundles, excitation of the ventricles occurs predominantly through the atrioventricular nodal system, ...

Respiratory sinus arrhythmia (RSA) is generally known as the autonomically mediated modulation of the sinus node pacemaker frequency in synchrony with respiration. Cardiorespiratory interactions have been largely investigated during sinus rhythm, whereas little is known about interactions during reentrant arrhythmias. In this study, cardiorespiratory interactions at the atrial and ventricular l...