A longer duration of untreated psychosis (DUP) has been associated with poor clinical outcomes in patients with schizophrenia (SZ); however, it remains unclear whether this is due to neurotoxic effects of psychosis. The purpose of this study was to use near-infrared spectroscopy (NIRS) to investigate the influence of DUP on brain function using two verbal fluency tests (VFTs) in patients with f...

Artemisinin has been demonstrated to exert beneficial effects on ventricular remodeling. The present study investigated whether artemisinin was able to decrease the ventricular fibrillation threshold (VFT) in rats following myocardial infarction (MI) and aimed to determine the possible underlying mechanisms. The rats were subjected to surgery to induce MI by ligation of the left anterior descen...

The Vogel-Fulcher-Tammann (VFT) equation has been used extensively in the analysis of the experimental data of temperature dependence of the viscosity or of the relaxation time in various types of supercooled liquids including metallic glass forming materials. In this article, it is shown that our model of viscosity, the Bond Strength-Coordination Number Fluctuation (BSCNF) model, can be used a...

BACKGROUND The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism has been associated with both overall schizophrenia risk and severity of negative symptoms. This study examined whether schizophrenia patients homozygous for the risk allele (T/T) exhibit greater impairment in executive function, and determined the extent to which MTHFR's effects on negative symptoms underlie this rel...

Photoinduced intra-molecular energy transfer in two ketoprofen(KP)-naproxol(NPX) diastereomers proceeds via two pathways. Very fast singlet–triplet energy transfer (k = 1.2 · 10 s ) from KP to NPX occurs for a small percentage (6%) and the major pathway is triplet–triplet energy transfer (k 3 · 10 s ). This was shown with femtosecond transient absorption spectroscopy and global and target analy...

BACKGROUND Tyrosine kinase receptors (RTKs) comprise a large family of membrane receptors that regulate various cellular processes in cell biology of diverse organisms. We previously described an atypical RTK in the platyhelminth parasite Schistosoma mansoni, composed of an extracellular Venus flytrap module (VFT) linked through a single transmembrane domain to an intracellular tyrosine kinase ...

PURPOSE Chemerin has been suggested to be linked to insulin resistance and type 2 diabetes mellitus (T2DM). However, the relationship between visceral adiposity and chemerin levels remains unclear in subjects with T2DM. In this study, we investigated the relationship between serum chemerin levels and visceral adiposity. MATERIALS AND METHODS This study included 102 subjects newly diagnosed wi...

a two-variable integrate and fire model is presented to study the role of transient outward potassium currents in producing temporal aspects of dorsal cochlear nucleus (dcn) pyramidal cells with different profiles namely the chopper, the pauser and the buildup. this conductance based model is a reduced version of km-lif model (meng & rinzel, 2010) which captures qualitative firing features of a...