Vesicular neurotransmitter transporters package transmitter into the lumen of synaptic vesicles for quantal release. However, the number of transporters that localize to each vesicle is not known. In this issue of Neuron, a study by Daniels et al. using the Drosophila neuromuscular junction and mutations of the vesicular glutamate transporter suggests that one transporter may suffice to fill ea...

Introduction: Radical radiation therapy of head and neck cancers may injure the salivary glands and reduce their function. Single-photon emission computed tomography (SPECT) images maybe used to evaluate function post-therapy. However, accurate quantification is hindered by the partial volume effects (PVEs). The present study involved the introduction of a PVEs quantif...

Simultaneous measurements of IVIEC and SCA by two nanotip electrodes allows direct dynamic comparison between vesicular transmitter content release to shed light on stimulation-induced plasticity.

Sixteen native ram lambs weaned at 10 wk of age were divided into two groups. Eight animals were immunized against LHRH with a mixture of two fusion proteins: ovalbumin-LHRH-7 and thioredoxin-LHRH-7. The immunized lambs received a primary immunization plus two booster immunizations at 4 and 12 wks. Animals in the control group (n=8) were not treated. Scrotal measurements and blood samples were ...

Objective(s): To review the findings of the patients with Sjögren’s syndrome (SS) having technetium-99m-pertechnetate (99mTc-pertechnetate) and gallium-67 citrate (Ga-67) salivary gland scintigraphy in the past eight years.Methods: The patients with SS, who were referred to our department for salivary gland scintigraphy during January 2008-December 2015 were studied using both 99mTc-pertechneta...

Background: Cadmium toxicity has been shown in aquatic animals but the effect on frog’s endocrine glands is not known. We investigated the effects of cadmium on ultimobranchial and parathyroid glands of Indian skipper frog, Euphlyctis cyanophlyctis. Methods: Frogs were exposed to cadmium chloride for short and long terms and sacrificed after 24, 48, 72 or 96 h (short-term) and after 5, 10, 1...

The ATP requirement during RNA transcription by the RNA-dependent RNA polymerase associated with purified vesicular stomatitis virus was studied during chain initiation and chain elongation steps. Initiation of transcription in vitro has an apparent Km for ATP of approximately 500 micron, whereas the apparent Km for ATP during chain elongation is almost identical with those for the other three ...

Lupi et al. present, on p. 80–81, an interesting case report of dyshidrosiform palmo-plantar pemphigoid. They describe a 20-year-old man who had had itchy vesicles on his palms and soles for 1 year. Histologically, a subepi-dermal vesicle was seen, and direct immunofluorescence showed continuous linear deposition of IgG and C 3 at the dermal-epidermal junction. An enzyme-linked immuno-sorbent a...