نتایج جستجو برای: vigabatrin
تعداد نتایج: 1095 فیلتر نتایج به سال:
The title compound, C(14)H(16)N(2)O(3), is an NH-vinyl-ogous amide (enaminone) produced by the reaction of 4-nitro-phenacyl bromide with azepane-2-thione. The conformation about the C=C bond [1.3927 (14) Å] is Z, which allows for the formation of an intra-molecular N-H⋯O hydrogen bond that leads to an S(6) loop. Inversion-related mol-ecules associate via N-H⋯O hydrogen bonds to form a 12-member...
Since their isolation almost 20 years ago, the callipeltosides have been of long standing interest to the synthetic community owing to their unique structural features and inherent biological activity. Herein we present our full research effort that has led to the synthesis of these molecules. Key aspects of our final strategy include 1) synthesis of the C1-C9 pyran core (5) using an AuCl3 -cat...
The title compound, C(14)H(8)Cl(3)NO(2)S, forms a dimeric structure by inter-molecular Cl⋯O=S inter-actions. The dimers make a two-dimensional array parallel to (101) by other Cl⋯O=S inter-actions. The two-dimensional network is found to be kept unchanged, although the trichloro-vinyl group is disordered (relative occupancies 0.65:0.35).
A divergent protocol for nucleophilic opening of vinyl epoxides with ethoxyacetylide has been developed and demonstrated to give complete regioselectivity depending on reaction conditions.
A unified approach for the construction of the potent marine antitumor agents (+)-tedanolide (1) and (+)-13-deoxytedanolide (2) is described. Highlights of the synthetic strategy include the development of a versatile bifunctional dithiane-vinyl iodide linchpin, the unorthodox use of the Evans-Tishchenko reaction, and a late-stage high-risk stereocontrolled introduction of the C(18,19) epoxide ...
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