It has been shown that during the early phase of lactation porcine milk contains high concentrations of hormones and growth factors. The aim of the present investigation was to examine the hypothesis that the temporal coordination of intestinal maturation in piglets can be extrinsically regulated through changes in the composition of milk during the suckling period. Gut morphology and the ontog...

BACKGROUND The functions of urokinase in intestinal epithelia are unknown. AIMS To determine the relation of urokinase expressed by intestinal epithelial cells to their position in the crypt-villus/surface axis and of mucosal urokinase activity to epithelial proliferative kinetics in the distal colon. METHODS Urokinase expression was examined immunohistochemically in human intestinal mucosa...

Mycobacterium avium ssp. paratuberculosis (MAP) is an infection of the ruminant intestine. In cows, a long subclinical phase with no or low intermittent shedding precedes the clinical phase with high shedding. It is generally considered that an adaptive cell-mediated immune response controls the infection during the subclinical phase, followed by unprotective antibodies later in life. Based on ...

BACKGROUND The role of intestinal glucose absorption in reducing glycemic levels after duodenojejunal bypass (DJB) is unclear. We hypothesized that DJB surgery decreases intestinal electrogenic glucose absorption by sodium glucose co-transporter 1 (SGLT1), leading to decreased glucose absorption and reduced blood glucose. Six groups of C57/BL6 mice were studied (n = 6 each) 2 weeks, 1 month, an...

BACKGROUND & AIMS Small intestinal mucosal ultrastructural abnormalities were reported in a limited number of patients with cholera in the 1970s. This study extends these observations by examining distal duodenal biopsy samples from 19 patients with cholera and 10 controls. METHODS Endoscopic biopsy samples obtained, usually during the first 24 hours of illness, were processed for electron mi...

this study was conducted to investigate the effects of garlic powder (gp) black seed (bs) and plant premix (gp and bs) in the diet on broiler growth performance and intestinal morphology. included 480 hubbard broiler chicks(day-old). there were 4 treatment groups each consisting of 3 replicates. the four dietary treatments consisted of a control (basal diet), basal diet +0.5% gp, basal diet +0....

We present a case of Cronkhite-Canada syndrome (CCS) in which the entire intestine was observed using a prototype of magnifying single-balloon enteroscope (SIF Y-0007, Olympus). CCS is a rare, non-familial gastrointestinal polyposis with ectodermal abnormalities. To our knowledge, this is the first report showing magnified intestinal lesions of CCS. A 73-year-old female visited our hospital wit...

A variety of enzymic and non-enzymic methods to isolate epithelium from the small intestine have been previously published. Sequential fractionation of cells from the villus to the crypt has been reported in some of these papers, which allows the comparative study of terminally differentiated and proliferative cell phenotypes. However, these methods often involve the incubation of tissues at 37...

An experimental model was established using the terminal ileum of the rat for characterizing and studying the effects of crude cell-free extract from Clostridium perfringens upon physiological and histological parameters involved in the transport process. Further work was done with the model system using purified enterotoxin (protein) from the cell extract. Using an in vivo perfusion technique ...

In the small intestine, the progeny of stem cells migrate in precise patterns. Absorptive, enteroendocrine, and goblet cells migrate toward the villus while Paneth cells occupy the bottom of the crypts. We show here that beta-catenin and TCF inversely control the expression of the EphB2/EphB3 receptors and their ligand ephrin-B1 in colorectal cancer and along the crypt-villus axis. Disruption o...