Plasma borne viruses Cell associated viruses Effective antiviral agents are still not yet available * Hepatitis B and delta agent * Cytomnegalovirus to treat most viral infections, so the safety of * Hepatitis A (rarely) * Epstein-Barr virus (more than blood and blood components has to rely solely on * Non-A, non-B hepatitis (one 95% of adults are immune) "self exclusion" by potential donors wh...

The zinc finger motifs in retroviral nucleocapsid (NC) proteins are essential for viral replication. Disruption of these Cys-X2-Cys-X4-His-X4-Cys zinc-binding structures eliminates infectivity. To determine if N-ethylmaleimide (NEM) can inactivate human immunodeficiency virus type 1 (HIV-1) or simian immunodeficiency virus (SIV) preparations by alkylating cysteines of NC zinc fingers, we treate...

transfusion of blood products from an infected person with aids, is meant to infect recipient. blood products such as whole blood, red blood cells, platelets, plasma, frozen blood precipitate, factor viii, factor ix, can be infected with hiv. transmissions from blood factors can be seen in plasma from thousands of donors that were collected in a container and were used to treat hemophilia. bloo...

the AxSYM, which showed an increase to 122%. From these data it is tempting to speculate that the Triton X-100 inactivation treatment could be useful for most commercial assays on high-throughput analyzers. However, it may well be that certain assays are more influenced by the presence of 1 mL/L Triton X-100 than others. These data suggest that it is possible to protect laboratory workers while...

Gammaherpesviruses chronically infect their host and are tightly associated with the development of lymphoproliferative diseases and lymphomas, as well as several other types of cancer. Mechanisms involved in maintaining chronic gammaherpesvirus infections are poorly understood and, in particular, little is known about the mechanisms involved in controlling gammaherpesvirus reactivation from la...

The latest experimental data on the role of viruses in the origin of human tumors are discussed. This group of viruses consists of T-cell leukemia virus type 1 (HTLV 1), herpes viruses (HHV 8 and Epstein-Barr virus), hepatitis B virus, and human papilloma viruses. The most typical feature of this group of viruses is a very long latent period from the initial infection to the development of the ...

BACKGROUND Hepatitis E virus (HEV) has been transmitted by transfusion of labile blood products and the occasional detection of HEV RNA in plasma pools indicates that HEV viremic donations might enter the manufacturing process of plasma products. To verify the safety margins of plasma products with respect to HEV, virus reduction steps commonly used in their manufacturing processes were investi...

pneumococcal autolysins are enzymes involved in cell wall turnover and cellular division physiologically. they have been found to be involved in the pneumococcus pathogenesis. the aim of this study was to identify the autolytic activity of spr1754 as a novel protein of streptococcus pneumoniae . moreover, the binding of the recombinant protein to plasma proteins was also determined. the spr1754...

BACKGROUND The multimeric size and platelet-tethering function of von Willebrand factor (VWF) are modulated by the plasma metalloprotease, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS-13). In vitro ADAMTS-13 is susceptible to proteolytic inactivation by thrombin. OBJECTIVES In this study, we aimed to characterize the inactivation of ADAMTS-13 by th...