Viral infections represent a major threat to human health and the global economy; however, most of currently available antiviral drugs are not fully effective in restricting viral replication selecting for drug-resistant variants. Targeted protein degradation technologies promising strategies avoid or delay emergence drug resistance. Among degradation-based multi-specific approaches, proteolysi...

The coronavirus disease-2019 (COVID-19) pandemic, caused by the pathogen severe acute respiratory syndrome 2 (SARS-CoV-2), started in China during late 2019 and swiftly spread worldwide. Since COVID-19 emergence, many therapeutic regimens have been relentlessly explored, although two vaccines just received emergency use authorization different governmental agencies, antiviral therapeutics based...

background and aims: celery mosaic virus (cemv) is one of the causal agents of viral diseases in celery (apium graveolens). cemv is a member of the potyvirus genus in potyviridae family. the virus is naturally transmitted by aphids in a non-persistent manner. during growing season 2006-2007 viral disease symptoms were observed in celery fields grown in tehran province (bage daneshkade, mohamads...

In cells that allow replication of vesicular stomatitis virus (VSV), there are two phases of translation inhibition: an early block of host translation and a later inhibition of viral translation. We investigated the phosphorylation of the alpha subunit of the eIF2 complex during these two phases of viral infection. In VSV-infected cells, the accumulation of phosphorylated (inactivated) eIF2alp...

The current treatments for coronavirus infections consist of monoclonal antibodies to prevent spike protein attachment and antiviral agents block RNA-dependent RNA polymerase interrupting viral replication. Fusion entry coronaviruses present new opportunities therapy are explained summarized in this report. Additional effective future will be great benefit globally.

background: rabies virus (rabv) is a deadly neurotropic virus that causes the disease of rabies in humans and animals. l protein is one of the large structural protein of rabies virus, which displays multiple enzymatic activities, and is required for viral transcription and replication.objectives: a truncated l protein of rabies virus is being cloned, expressed and purified to produce relevant ...

Early studies of HIV infection dynamics suggested that virus-producing HIV-infected cells had an average half-life of approximately 1 day. However, whether this average behavior is reflective of the dynamics of individual infected cells is unclear. Here, we use HIV-enhanced green fluorescent protein (EGFP) constructs and flow cytometry sorting to explore the dynamics of cell infection, viral pr...