Mucinous ovarian tumors are the second commonest type of epithelial ovarian tumors. Most of these tumors are benign. Occasionally, these tumors may reach enormous dimensions without being symptomatic. We reported the occurrence of a huge benign ovarian tumor (mucinous cystadenoma) in Nnewi. The data were collected from history taking, clinical examination, laboratory investigation, ultrasonogra...

Primary ovarian carcinoma is a heterogeneous group of diseases and each subtype is characterized by distinct clinical, histologic, and molecular features. Ovarian cancers can be broadly subdivided into Type I and Type II tumors. This classification is not a histologic one, but describes tumorigenic pathways based on clinically correlated molecular data. Type I tumors include low-grade serous, l...

In humans and canines, the morphology of granulosa cell tumors is extremely variable and causes diagnostic difficulties. In human pathology, immunohistochemistry has been widely used for the diagnosis of granulosa cell tumors, whereas, limited studies are present in canine species. The aim of this study was to investigate the expression of cytokeratins, vimentin, and inhibin-alpha in canine nor...

from december 2000 until 2010, the researchers at royan institute conducted a wide range of investigations on ovarian tissue cryopreservation with the intent to provide fertility preservation to cancer patients that were considered to be candidates for these services. in 2010, royan institute established the royan human ovarian tissue bank as a subgroup of the embryology department. since its i...

PURPOSE Heparan sulfate proteoglycans have been implicated in cancer cell growth, invasion, metastasis, and angiogenesis. This study was designed to compare their expression in normal ovary and ovarian tumors and then to examine their prognostic significance in ovarian cancer. EXPERIMENTAL DESIGN The expression of syndecan-1, -2, -3, and -4, glypican-1, and perlecan was assessed by immunohist...

Ovarian borderline (low malignant potential) tumors are a puzzling group of neoplasms that do not fall neatly into benign or malignant categories. Their behavior is enigmatic, their pathogenesis unclear, and their clinical management controversial, especially for serous borderline tumors (SBT), the most common type of ovarian borderline tumor. Clarifying the nature of borderline tumors and thei...

clear cell adenofibromas of borderline malignancy are extremely rare tumors of the ovaries. they may be associated with ovarian clear cell adenocarcinomas which typically present as large adnexal masses and are generally considered highly malignant. we describe the case of a postmenopausal female with an ovarian mass diagnosed as atypical (borderline) proliferating clear cell adenofibroma. the ...

The incidence of ovarian cancer depends on the ethnicity and geographical area. Menopausal status is a well-known risk factor for ovarian cancer and most cases occur after menopause in Caucasians. However, it is less clear how the status of menopause or age at diagnosis is associated with ovarian cancer including its subtypes in Chinese women. Data on 1,283 women with primary malignant or borde...

BACKGROUND Although BRCA1 and BRCA2 play important roles in hereditary ovarian cancers, the extent of their role in sporadic ovarian cancers and their mechanisms of inactivation are not yet well understood. Our goal was to characterize BRCA2 mutations and mRNA expression in a group of ovarian tumors previously evaluated for BRCA1 mutations and mRNA expression. METHODS The tumors of 92 unrelat...

Ovarian metastases can account for as many as 30–40% of all ovarian malignancies1–3. The potential for metastatic tumors to mimic the clinical and morphologic appearance of primary ovarian tumors is well known to surgical pathologists2. Correct diagnosis and successful management of patients with these diseases often rely on the degree of distinction between primary and metastatic tumors. Most ...