Basal cell carcinoma is the most common skin cancer, with a very low incidence of metastases, associated high morbidity and mortality. The morpheaform clinical variant uncommon, presenting an aggressive growth pattern. Early diagnosis new targeted therapies for metastatic disease are important to improve survival rates. We present case 29-year-old patient basal in right genian region. Due local...

The ciliary localization of odorant receptors (ORs) is evolutionary conserved and essential for olfactory transduction. However, how the transport of ORs is regulated in mammalian olfactory sensory neurons is poorly understood. Here we demonstrate that odorant responsiveness and OR transport is regulated by the Hedgehog pathway. OR transport is inhibited by conditional gene inactivation of the ...

We present a 103 - year - old patient, with duration of complaints of about ten years. The initial complaint had been presented as a small nodule, located on the eyebrow, which subsequently ulcerated and encompassed larger regions of the upper and lower eyelids. For the past three years, the patient also had complaints of a worsening of his vision, without seeking for medical help. Within the d...