Background: Cyclosporine A (CsA) is a nephrotoxic immunosuppressive drug. Antioxidants might attenuate its toxicity. In the present study, the effects of vitamin E and quercetin on the morphology of kidney in CsA-treated rats were investigated. Methods: Six groups of rats were used in this gavage feeding study either for 4 or 8 weeks. Groups 1 and 2 received either olive oil or 25% ethanol in o...

Background: Osteoporosis one of the postmenopausal symptoms is characterized by bone loss. There is a link between excessive reactive oxygen species (ROS) formation, estrogen deficiency due to cessation of ovarian function and bone loss. Free radicals are responsible for causing osteoblast apoptosis and reducing osteoblastogenesis in bone remodeling. Vitamin E is a potent antioxidant with the a...

Fumarate reductase from Escherichia coli functions both as an anaerobic fumarate reductase and as an aerobic succinate dehydrogenase. A site-directed mutation of E. coli fumarate reductase in which FrdB Pro-159 was replaced with a glutamine or histidine residue was constructed and overexpressed in a strain of E. coli lacking a functional copy of the fumarate reductase or succinate dehydrogenase...

Background and aim: Psoriasis is a common chronic inflammatory and proliferative disease that genetic and environmental factors have a role in its pathogenesis and duration. The objective of this study was to compare the levels of vitamin A and E in the serum of psoriasis patients and control group.Materials and methods: We evaluated 30 psoriasis patients and 30 healthy...

Although NAD(+)-dependent succinate semialdehyde dehydrogenase activity was first described in Escherichia coli more than 25 years ago, the responsible gene has remained elusive so far. As an experimental proof of concept for a gap-filling algorithm for metabolic networks developed earlier, we demonstrate here that the E. coli gene yneI is responsible for this activity. Our biochemical results ...

BACKGROUND Succinate is a kind of industrially important C4 platform chemical for synthesis of high value added products. Due to the economical and environmental advantages, considerable efforts on metabolic engineering and synthetic biology have been invested for bio-based production of succinate. Precursor phosphoenolpyruvate (PEP) is consumed for transport and phosphorylation of glucose, and...

1. The effects of a number of free-radical scavengers and other agents on the stimulation of malonaldehyde production due to low concentrations of carbon tetrachloride have been studied in rat liver microsome suspensions. 2. Promethazine, propyl gallate and NN'-diphenyl-p-phenylenediamine were extremely active in inhibiting the stimulation of malonaldehyde production due to carbon tetrachloride...

asthma is a chronic inflammatory airway disorder and the most common chronic disease among children characterized by frequent and chronic cough, wheezing, and dyspnea. asthma is defined as an inflammatory process in response to t- helper 2 cells. vitamin e as a lipid soluble vitamin containing 4 isomers α, β, γ, б, with α- tocopherol as the most important isomer is an important defensive agent ...

BACKGROUND Previous work has demonstrated that vitamin E succinate (VES), an ester analogue of vitamin E, inhibits the growth of melanoma in vitro. However, there is no information about the effect of VES on melanoma in vivo. We investigated the effect of VES on melanoma in vitro and in vivo. METHODS The effect of VES on the proliferation and apoptosis of the B16F10 murine melanoma cell line ...