Type Vicenza variant of von Willebrand disease (VWD) is characterized by a low plasma von Willebrand factor (VWF) level and supranormal VWF multimers. Two candidate mutations, G2470A and G3864A at exons 17 and 27, respectively, of the VWF gene were recently reported to be present in this disorder. Four additional families, originating from northeast Italy, with both mutations of type Vicenza VW...

Type 1 von Willebrand disease (VWD) is characterized by a partial quantitative deficiency of von Willebrand factor (VWF). Few VWF gene mutations have been identified that cause dominant type 1 VWD. The decreased survival of VWF in plasma has recently been identified as a novel mechanism for type 1 VWD. We report 4 families with moderately severe type 1 VWD characterized by low plasma VWF:Ag and...

Von Willebrand disease type 3 (VWD3) is the most severe form of this bleeding disorder due to the almost complete deficiency of von Willebrand factor (VWF). VWD3 is inherited as an autosomal recessive trait. While heterozygous carriers exhibit mild or no bleeding symptoms, most patients with VWD3, which is characterized by undetectable levels of VWF antigen (VWF:Ag) and reduced concentrations (...

P lastic surgery is one of the most ancient forms of surgery, and its roots can be traced back to the time of Sushruta, the father of surgery (600 BC), 1 who is credited with performing the first ever reported plastic surgical procedures. The name, however , defies a clear understanding and an appropriate definition that could cover the entire scope of activities performed at the present moment...

A clinical and pathological atlas. The records of a surgeon in St Vincent, The West Indies. Cecil Cyrus began his studies at Queen's in 1950 and passed his Final MB in 1957. Along the way he worked hard collecting several prizes in his professional examinations, the Symington medal, and a BSc in Anatomy. After a few years he passed his FRCS in England and Edinburgh and gained extensive postgrad...

es wird gezeigt, dass bei der standiger zunahme der production von roheisen ,die fast ausschliesslich in hochofen erfolgt, der gestelldurchmesser und die ofeneinheit zunimmt demgegenuber der spezifische brennstoffverbrauch abnimmt. weiterhin wird die entwicklungsrichtung der stahlerzeungsverfanren wegen der wirtschaftlichen und technischen hinsicht untersucht und festgestellt, dass nuter versch...

von Willebrand disease (VWD) was first described nearly a century ago in 1924 by Erik Adolf von Willebrand. Diagnostic testing at the time was very limited and it was not until the mid to late 1900s that more tests became available to assist with the diagnosis and classification of VWD. Two of these tests are based on ristocetin, one being ristocetin-induced platelet aggregation (RIPA) and the ...

Type I von Willebrand disease (vWD) is very common in caucasians. Its genetic basis is possibly heterogenous, lying both within and out of the vWF gene locus. We sought to investigate vWF levels in the Thai population, to compare with those of western countries. The vWF antigen and activity were measured using ELISA and Collagen Binding Assay (CBA), respectively, in 311 healthy Thai volunteers....