PTB-associated splicing factor (PSF) is an abundant and essential nucleic acid-binding protein that participates in a wide range of gene regulatory processes and cellular response pathways. At the protein level, PSF consists of multiple domains, many of which remain poorly characterized. Although grouped in a family with the proteins p54nrb/NONO and PSPC1 based on sequence homology, PSF contain...

OBJECTIVES To investigate if the population living along streets with high traffic density has a higher prevalence of chronic respiratory symptoms. METHODS A sample of 673 adults and 106 children (0-15 years), living along busy traffic streets in the city of Haarlem was compared with a control sample of 812 adults and 185 children living along quiet streets. Exposed and control streets were s...

Emergency departments (EDs) are an important diagnostic site for outpatients with potentially serious infections. EDs frequently experience high patient volumes, and crowding has been shown to negatively impact the delivery of early care for serious infections, such as pneumonia. Here, we hypothesized that other important factors in the early care of infectious diseases, the rate of blood cultu...

In a time of increased patient loads and emergency department (ED) exit block, the need for strategies to manage patient flow in the ED has become increasingly important. In March 2002 we contacted all 1282 members of the Canadian Association of Emergency Physicians and asked them to delineate strategies for enhancing ED patient flow and ED productivity without increasing stress levels, reducin...

F or 21st-century businesses, the problem is not accessing data but ignoring irrelevant data. Most modern businesses can electronically access mountains of data such as transactions for the past two years or the state of their assembly line. The trick is effectively using the available data. In practice, this means summarizing large data sets to find the “pearls in the dust”—that is, the data t...

Abstract: In the teletraffic engineering of all the telecommunication networks, parameters characterizing the terminal traffic are used. One of the most important of them is the probability of finding the called (B-terminal) busy. This parameter is studied in some of the first and last papers in Teletraffic Theory. We propose a solution in this topic in the case of (virtual) channel systems, su...

Introduction Hematologic malignancies (HM) represent the most common neoplasms in childhood. Despite improved overall survival rates, they are still a major contributor to cancer death in children. Aims To determine the proportion of children with HM in pediatric palliative care (PPC) and to identify the clinical characteristics and symptoms in comparison to children with extracranial solid t...

Degree apprenticeships in the UK represent a shift approach to degree-level study. As model matures, it is important hear perspectives of apprentices. Using Q methodology, study aims identify different apprentices’ viewpoints apprenticeship, exploring aspects belonging, support, challenges and views learning experience. Thirty-five second-year computing apprentices at university participated Ce...