Using 11C-Pittsburgh compound B (PiB)-PET and MRI volume data, we investigated whether white matter (WM) PiB uptake in Alzheimer's disease (AD) brain is larger than that of cortical PiB uptake-negative (PiB-negative) brain. Forty-five subjects who underwent both PiB-PET and MRI were included in the study (32 AD patients with cortical PiB-positive and 13 cortical amyloid -negative patients). Ind...

In the study of many neurological pathologies, the accurate quantization of the white matter (WM) and gray matter (GM) volumes of the brain is essential. Moreover, regional volume calculations may bring even more useful diagnostic information. In this paper, we present therefore the segmentation of internal structures of the brain for further regional WM and GM volume quantization. A priori inf...

Multiple sclerosis (MS) is an immune-mediated disease affecting central nervous system (CNS). Although MS is classically considered a white matter (WM) disease, the involvement of gray matter (GM) in the pathogenic process has been confirmed by pathology studies and MRI studies. Impairment of cognitive domains such as memory, mental processing speed, attention, and executive function can occur ...

There are some conflicts about constancy of conduction velocity (CV) in a given tract of nervous system. By recording excitatory postsynaptic currents (EPSC) in layer IV of the somatosensory cortex we tried to clear changes in CV of thalamocortical tract of mice aged 3 to 50 days old. Field potentials and EPSC were recorded in the layer IV by stimulation of ventrobasal nucleus of thalamus (VB) ...

BACKGROUND The pathology of delusions in patients with Alzheimer's disease (AD) associated with white matter (WM) abnormalities is poorly understood. In addition, whether the abnormalities in WM integrity that underlie the delusions develop before the onset of the delusions remains unclear. In this study, we used a diffusion tensor imaging approach to examine the existence of baseline abnormali...

OBJECTIVE Little is known about the mechanisms by which obesity influences brain structure. In this study, the obesity-related changes in brain white and gray matter integrity were examined. DESIGN AND METHODS 23 morbidly obese subjects and 22 nonobese volunteers were studied using voxel-based analysis of diffusion tensor imaging and of T1-weighted MRI images. Full-volume statistical parametr...

Atlases of key white matter (WM) structures in humans are widely available, and are very useful for region of interest (ROI)-based analyses of WM properties. There are histology-based atlases of cortical areas in the rhesus macaque, but none currently of specific WM structures. Since ROI-based analysis of WM pathways is also useful in studies using rhesus diffusion tensor imaging (DTI) data, we...

OBJECTIVE To measure brain volume deficits among underweight patients with anorexia nervosa (AN) compared to control participants and evaluate the reversibility of these deficits with short-term weight restoration. METHOD Brain volume changes in gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) were examined in 32 adult women with AN and compared to 21, age and body mass inde...

The present study aims to estimate the in vivo anisotropic conductivities of the White Matter (WM) tissues by means of Magnetic Resonance Electrical Impedance Tomography (MREIT) technique. The realistic anisotropic volume conductor model with different conductivity properties (scalp, skull, CSF, gray matter and WM) is constructed based on the Diffusion Tensor Magnetic Resonance Imaging (DT-MRI)...

This study created a database of pediatric age-specific magnetic resonance imaging (MRI) brain templates for normalization and segmentation. Participants included children from 4.5 through 19.5 years, totaling 823 scans from 494 subjects. Open-source processing programs (FMRIB Software Library, Statistical Parametric Mapping, Advanced Normalization Tools [ANTS]) constructed head, brain, and seg...